| Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome. | |
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MedLine Citation:
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PMID: 19318028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque. |
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Authors:
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Kasper K Iversen; Ane S Teisner; Borge Teisner; Anette Kliem; Pia Thanning; Henrik Nielsen; Peter Clemmensen; Peer Grande |
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Publication Detail:
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Type: Journal Article Date: 2009-02-04 |
Journal Detail:
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Title: Clinical biochemistry Volume: 42 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 828-34 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hillerod Hospital, Helsevej 2, 3400 Hillerod, Denmark. kasper.iversen@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood* Adult Aged Aged, 80 and over Electrocardiography Female Humans Male Middle Aged Pregnancy-Associated Plasma Protein-A / diagnostic use*, metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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