Document Detail

Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome.
MedLine Citation:
PMID:  19318028     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). DESIGN AND METHODS: Consecutively admitted patients (N=573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. RESULTS: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P<0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. CONCLUSION: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.
Kasper K Iversen; Ane S Teisner; Borge Teisner; Anette Kliem; Pia Thanning; Henrik Nielsen; Peter Clemmensen; Peer Grande
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Publication Detail:
Type:  Journal Article     Date:  2009-02-04
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  828-34     Citation Subset:  IM    
Department of Cardiology, Hillerod Hospital, Helsevej 2, 3400 Hillerod, Denmark.
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MeSH Terms
Acute Coronary Syndrome / blood*
Aged, 80 and over
Middle Aged
Pregnancy-Associated Plasma Protein-A / diagnostic use*,  metabolism
Young Adult
Reg. No./Substance:
EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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