| Pregnancy-associated plasma protein-A and placental protein 5 in human ovarian follicular fluid. | |
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MedLine Citation:
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PMID: 2409857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By sensitive and specific radioimmunoassays PAPP-A and PP5 were detected in follicular aspirates obtained from women undergoing ovarian hyperstimulation for oocyte harvest prior to in vitro fertilization and embryo transfer. Follicular and pregnancy-derived PAPP-A were immunologically and physicochemically indistinguishable. Similarly, pregnancy- and nonpregnancy-derived PP5 were immunologically indistinguishable. However, in addition to the 18- and 36-K species, a larger species having a molecular size greater than 140K was found in the follicular fluid. Mean follicular PAPP-A and PP5 concentrations were 727 mIU/L and 1376 mAU/L, respectively, with no significant correlation between follicular PAPP-A, PP5, and steroid concentrations. There was, however, a significant but negative relationship with follicular volume. Preliminary in vitro studies indicated that both proteins were synthesized by granulosa cells in preparation for follicular rupture. Follicular PP5, like antithrombin III, interacted reversibly with heparin and thrombin affinity matrices, suggesting a potential biological role as a follicular anticoagulant, whereas PAPP-A, a specific and potent inhibitor of leukocyte elastase, contributes to the maintenance of proteolytic homeostasis and the protection of spermatozoa and embryo against proteolytic attack originating from the maternal leukocytes. |
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Authors:
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M J Sinosich; D M Saunders; J G Grudzinskas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 442 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-08-06 Completed Date: 1985-08-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 269-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Culture Media Embryo, Mammalian / physiology Estradiol / analysis Female Glycoproteins* Humans Ovarian Follicle / analysis* Pregnancy Pregnancy Proteins / analysis*, physiology Pregnancy-Associated Plasma Protein-A / analysis*, physiology Progesterone / analysis Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Glycoproteins; 0/Pregnancy Proteins; 0/tissue-factor-pathway inhibitor 2; 50-28-2/Estradiol; 57-83-0/Progesterone; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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