Document Detail

Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs.
MedLine Citation:
PMID:  17218136     Owner:  NLM     Status:  MEDLINE    
Pregnancy-associated plasma protein-A (PAPP-A) was originally isolated in 1974, as one of four proteins of placental origin found in high concentrations in the blood of pregnant women. In the early 1990s several laboratories reported novel protease activity against insulin-like growth factor binding protein-4 (IGFBP-4) in media conditioned by several cell types. This activity was unique, as it appeared to require the presence of IGF to cleave IGFBP-4. In 1999, this IGF-dependent IGFBP-4 protease activity was isolated from human fibroblast conditioned media and identified as PAPP-A. Subsequently, PAPP-A was shown to be expressed by a variety of cell types, and thus no longer could be considered to be just "pregnancy-associated". This review will describe what is currently known about the structure of PAPP-A and about its function as an IGFBP protease, with a focus on new insights obtained through study of a PAPP-A knock-out mouse model and on potential clinical applications.
Henning B Boldt; Cheryl A Conover
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-10
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  17     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-06-12     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  10-8     Citation Subset:  IM    
Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5-194 Joseph, Rochester, MN 55905, USA.
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MeSH Terms
Amino Acid Sequence
Gene Expression Regulation
Insulin-Like Growth Factor Binding Proteins / metabolism*
Models, Biological
Molecular Sequence Data
Pregnancy-Associated Plasma Protein-A / chemistry,  genetics,  metabolism,  physiology*
Protein Processing, Post-Translational
Protein Structure, Tertiary
Sequence Homology, Amino Acid
Somatomedins / metabolism*
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Proteins; 0/Somatomedins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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