Document Detail

Pregnancy-associated lymphomas. A clinicopathologic study.
MedLine Citation:
PMID:  8674008     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The natural histories of Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHL) during pregnancy are not well understood. METHODS: All cases of HD and NHL diagnosed during pregnancy at Stanford University Medical Center since 1987 were reviewed and clinical follow-up was obtained. Various immunohistochemical studies and in situ hybridization for Epstein-Barr virus (EBV) encoded RNA were performed in a subset of cases. RESULTS: Seventeen cases of HD and 12 cases of NHL were accessioned (median age; 27 yrs). The HD cases were classified as 13 nodular sclerosis type, 3 mixed cellularity type, and 1 unclassified. Clinical follow-up revealed most of the patients had Stage II to III disease and were diagnosed on average at 22 weeks gestation. Most of the patients deferred therapy until after delivery and had no evidence of disease at the last follow-up except for one death with disease but not from it. NHL were classified according to the working formulation as high or intermediate grade lymphomas of various types, including both nodal and extranodal sites. Clinical follow-up revealed most had Stage II to IV disease and were diagnosed on average at 23 weeks gestation. Patients with HD tended to survive longer than those with NHL (raw mortality, P = 0.04). In situ hybridization failed to provide support for the presence of EBV in a subset of patients with NHL. CONCLUSIONS: The clinical behavior of these neoplasms during pregnancy does not appear to be significantly different from that outside of the setting of pregnancy. Treatment of selected HD patients apparently may be safely deferred until after delivery. Patients with NHL present with higher stage disease and have a poorer prognosis than those with HD.
A B Gelb; M van de Rijn; R A Warnke; O W Kamel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  78     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-15     Completed Date:  1996-08-15     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-10     Citation Subset:  AIM; IM    
Department of Pathology, University of California, San Francisco 94143-0102, USA.
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MeSH Terms
Combined Modality Therapy
Delivery, Obstetric
Follow-Up Studies
Gestational Age
Herpesvirus 4, Human / genetics
Hodgkin Disease / drug therapy,  pathology*,  virology
In Situ Hybridization
Lymphoma, B-Cell / pathology
Lymphoma, Large B-Cell, Diffuse / pathology
Lymphoma, Non-Hodgkin / drug therapy,  pathology*,  virology
Neoplasm Staging
Pregnancy Complications, Neoplastic / pathology*,  virology
RNA, Viral / genetics,  isolation & purification
Retrospective Studies
Survival Rate
Grant Support
Reg. No./Substance:
0/RNA, Viral
Comment In:
Cancer. 1997 Jan 1;79(1):191-2   [PMID:  8988748 ]

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