| Pregnancy-associated homeostasis and dysregulation: Lessons from genetically modified animal models. | |
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MedLine Citation:
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PMID: 21613291 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Physiological alterations occur in many organ systems during pregnancy. These changes are necessary for the adaptation to pregnancy-specific physiological processes in mother and fetus, and the placenta plays a critical role in the maintenance of homeostasis in pregnancy. Dysregulation of these functional feto-maternal interactions leads to severe complications. There have been many attempts to create animal models that mimic the hypertensive disorders of pregnancy, especially preeclampsia. In this review, we summarize the physiology of pregnancy and placental function, and discuss the placental gene expression in normal pregnancy. In addition, we assess a number of established animal models focusing on a specific pathogenic mechanism of preeclampsia, including genetically modified mouse models involving the renin angiotensin system. Validation of these animal models would contribute significantly to understanding the basic principles of pregnancy-associated homeostasis and the pathogenesis of preeclampsia. |
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Authors:
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Junji Ishida; Toshiki Matsuoka; Tomoko Saito-Fujita; Saki Inaba; Satoshi Kunita; Fumihiro Sugiyama; Ken-Ichi Yagami; Akiyoshi Fukamizu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: Journal of biochemistry Volume: - ISSN: 1756-2651 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Life Science Center, Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan; and Laboratory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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