Document Detail

Pregnancy associated aplastic anaemia: a report of five cases and review of current management.
MedLine Citation:
PMID:  2611139     Owner:  NLM     Status:  MEDLINE    
The occurrence of aplastic anaemia in pregnancy has been long recognized but its rarity has made it difficult to establish the relationship between the two conditions and the optimal management. We now report five cases of aplastic anaemia in pregnancy and offer some recommendations for treatment. In two patients the pregnancy was allowed to continue to term and the disease persisted post-partum leading to death in one case. The other three patients had their pregnancies terminated; one subsequently deteriorated and died, two had spontaneous remissions of their aplasia. We suggest that patients presenting with severe aplastic anaemia in early pregnancy should be offered termination because this may be followed by haematological improvement. If haematological improvement does not occur allogeneic bone marrow transplantation (BMT) may be considered. Aplastic anaemia presenting in late pregnancy should be treated with supportive care until delivery. On the basis of our experience, antilymphocyte globulin may safely be given during pregnancy.
R G Aitchison; J C Marsh; J M Hows; N H Russell; E C Gordon-Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  73     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-05     Completed Date:  1990-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  541-5     Citation Subset:  IM    
Royal Postgraduate Medical School, Hammersmith Hospital, London.
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MeSH Terms
Abortion, Induced
Anemia, Aplastic / therapy*
Antilymphocyte Serum / therapeutic use
Bone Marrow Transplantation
Pregnancy Complications, Hematologic / therapy*
Reg. No./Substance:
0/Antilymphocyte Serum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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