Document Detail


Pregnancy-associated Sweet's syndrome in an acute episode of ulcerative colitis.
MedLine Citation:
PMID:  19662588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 33-year old pregnant patient (pregnancy week 15) with a past medical history of ulcerative colitis with onset of the disease following the birth of her first child was admitted to the hospital with symptoms of weight loss, pyrexia, leukocytosis and bloody and mucous diarrhoea. Total ileocolonoscopy revealed an acute flare of ulcerative colitis. Within a few days, tender erythematous skin lesions occurred and were histologically proven to be neutrophilic dermatosis. Treatment with highly-dosed prednisone led to a complete remission of both cutaneous and intestinal manifestations. Both pathogenic entities are associated with similar immunological alterations, such as comparable cytokine and chemokine release patterns and recruitment of inflammatory cells. Recent data also indicates that proinflammatory cytokine levels are elevated in pregnancy, which might be pivotal in the pathogenesis and the severity of intestinal and extraintestinal symptoms. We present and discuss a diagnostic algorithm and an overall therapeutic rationale for Sweet's syndrome.
Authors:
J Best; A Dechene; S Esser; G Gerken; A Canbay
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-08-06
Journal Detail:
Title:  Zeitschrift für Gastroenterologie     Volume:  47     ISSN:  1439-7803     ISO Abbreviation:  Z Gastroenterol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-07     Completed Date:  2009-10-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0033370     Medline TA:  Z Gastroenterol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  753-7     Citation Subset:  IM    
Copyright Information:
Copyright Georg Thieme Verlag KG Stuttgart. New York.
Affiliation:
Department of Gastroenterology and Hepatology, University Hospital Essen, 45122 Essen.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Colitis, Ulcerative / diagnosis*,  therapy*
Female
Humans
Pregnancy
Pregnancy Complications / diagnosis*,  therapy*
Sweet Syndrome / diagnosis*,  therapy*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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