Document Detail


Pregnancy and amyloidosis: II. Suppression of amyloidogenesis during pregnancy.
MedLine Citation:
PMID:  11039852     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The observation of a deleterious effect of pregnancy on kidney function in amyloidosis of familial Mediterranean fever suggests that pregnancy may enhance amyloidogenesis. To determine whether pregnancy may indeed affect amyloidogenesis, pregnant mice were made amyloidotic by administration of amyloid-enhancing factor (AEF) and AgNO3 at different points in time from conception, and amyloid- deposition was studied with the crush-and-smear technique. A possible effect of exogenous female sex hormones (beta-estradiol and progesterone) on amyloidogenesis was studied by administration of these hormones during amyloid induction in nonpregnant female mice. Amyloidogenesis was found to be significantly suppressed in mice during pregnancy. The reduction was possibly related to the effect of pregnancy on the inflammatory stimulus (AgNO3) and not on the administered AEF. Exogenous estrogen and progesterone failed to inhibit amyloidogenesis in nonpregnant mice. These findings suggest that pregnancy may suppress amyloidogenesis in mice. The suppression is caused by an anti-inflammatory effect of pregnancy. Estrogen and progesterone are probably unrelated to this finding.
Authors:
S Shtrasburg; M Pras; M Dolitzky; C Pariente; R Gal; A Livneh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  136     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-27     Completed Date:  2000-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  314-9     Citation Subset:  AIM; IM    
Affiliation:
Heller Institute of Medical Research, and the Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Descriptor/Qualifier:
Amyloidosis / chemically induced,  physiopathology*
Animals
Estrogens / blood,  pharmacology
Female
Glycoproteins
Male
Mice
Pregnancy
Pregnancy, Animal / physiology*
Progesterone / blood,  pharmacology
Silver Nitrate
Spleen / pathology
Chemical
Reg. No./Substance:
0/Estrogens; 0/Glycoproteins; 0/amyloid enhancing factor; 57-83-0/Progesterone; 7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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