Document Detail

Pregnancy and amyloidosis: II. Suppression of amyloidogenesis during pregnancy.
MedLine Citation:
PMID:  11039852     Owner:  NLM     Status:  MEDLINE    
The observation of a deleterious effect of pregnancy on kidney function in amyloidosis of familial Mediterranean fever suggests that pregnancy may enhance amyloidogenesis. To determine whether pregnancy may indeed affect amyloidogenesis, pregnant mice were made amyloidotic by administration of amyloid-enhancing factor (AEF) and AgNO3 at different points in time from conception, and amyloid- deposition was studied with the crush-and-smear technique. A possible effect of exogenous female sex hormones (beta-estradiol and progesterone) on amyloidogenesis was studied by administration of these hormones during amyloid induction in nonpregnant female mice. Amyloidogenesis was found to be significantly suppressed in mice during pregnancy. The reduction was possibly related to the effect of pregnancy on the inflammatory stimulus (AgNO3) and not on the administered AEF. Exogenous estrogen and progesterone failed to inhibit amyloidogenesis in nonpregnant mice. These findings suggest that pregnancy may suppress amyloidogenesis in mice. The suppression is caused by an anti-inflammatory effect of pregnancy. Estrogen and progesterone are probably unrelated to this finding.
S Shtrasburg; M Pras; M Dolitzky; C Pariente; R Gal; A Livneh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  136     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-27     Completed Date:  2000-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  314-9     Citation Subset:  AIM; IM    
Heller Institute of Medical Research, and the Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amyloidosis / chemically induced,  physiopathology*
Estrogens / blood,  pharmacology
Pregnancy, Animal / physiology*
Progesterone / blood,  pharmacology
Silver Nitrate
Spleen / pathology
Reg. No./Substance:
0/Estrogens; 0/Glycoproteins; 0/amyloid enhancing factor; 57-83-0/Progesterone; 7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Activated platelets adherent to an intact endothelial cell monolayer bind flowing neutrophils and en...
Next Document:  Serum soluble Fas (CD95) and Fas ligand profiles in chronic kidney failure.