Document Detail


Pregnancy alters cerebrovascular adaptation to high-altitude hypoxia.
MedLine Citation:
PMID:  8160869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously shown alterations in cerebrovascular composition, contractility, and endothelial function in normoxic pregnant (P) and chronically hypoxic nonpregnant (HNP) adult sheep compared with nonpregnant normoxic controls (NP). This study focuses on a fourth group, pregnant sheep exposed to chronic high-altitude hypoxia (HP) (110 days at 3,820 m). The combined challenges of pregnancy and high-altitude hypoxia resulted in significant alterations in cerebrovascular function that were not simply the summation of the responses seen in the P and HNP animals. Compared with NP, HP arteries had increased protein content and increased intracranial arterial wall thickness. Both P and HP arteries showed increased contractility, while HNP artery maximum tensions were depressed. Endothelial function was depressed in the P common carotid and was enhanced in all HNP arteries. In contrast, an increased endothelial response was shown only in the HP common carotid. Thus, for contractility, the effects of pregnancy predominated in the HP arteries. For endothelial function, hypoxia effects were dominant in the common carotid but not in the intracranial arteries. Clearly, cerebrovascular characteristics are dynamic in nature, with artery-specific responses to both pregnancy and hypoxia.
Authors:
A D Hull; L D Longo; D M Long; W J Pearce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R765-72     Citation Subset:  IM    
Affiliation:
Department of Physiology, Loma Linda University School of Medicine, California 92350.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Altitude*
Animals
Anoxia / etiology*,  physiopathology*
Blood Vessels / drug effects,  metabolism,  pathology
Calcimycin / pharmacology
Cerebrovascular Circulation*
Female
Penicillamine / analogs & derivatives,  pharmacology
Pregnancy
Pregnancy Complications*
S-Nitroso-N-Acetylpenicillamine
Sheep
Vasoconstriction
Vasodilation
Grant Support
ID/Acronym/Agency:
HD-03807/HD/NICHD NIH HHS; HL-41347/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
52-67-5/Penicillamine; 52665-69-7/Calcimycin; 79032-48-7/S-Nitroso-N-Acetylpenicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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