| Pregnancy alters cerebrovascular adaptation to high-altitude hypoxia. | |
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MedLine Citation:
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PMID: 8160869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously shown alterations in cerebrovascular composition, contractility, and endothelial function in normoxic pregnant (P) and chronically hypoxic nonpregnant (HNP) adult sheep compared with nonpregnant normoxic controls (NP). This study focuses on a fourth group, pregnant sheep exposed to chronic high-altitude hypoxia (HP) (110 days at 3,820 m). The combined challenges of pregnancy and high-altitude hypoxia resulted in significant alterations in cerebrovascular function that were not simply the summation of the responses seen in the P and HNP animals. Compared with NP, HP arteries had increased protein content and increased intracranial arterial wall thickness. Both P and HP arteries showed increased contractility, while HNP artery maximum tensions were depressed. Endothelial function was depressed in the P common carotid and was enhanced in all HNP arteries. In contrast, an increased endothelial response was shown only in the HP common carotid. Thus, for contractility, the effects of pregnancy predominated in the HP arteries. For endothelial function, hypoxia effects were dominant in the common carotid but not in the intracranial arteries. Clearly, cerebrovascular characteristics are dynamic in nature, with artery-specific responses to both pregnancy and hypoxia. |
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Authors:
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A D Hull; L D Longo; D M Long; W J Pearce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 266 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-05-19 Completed Date: 1994-05-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R765-72 Citation Subset: IM |
Affiliation:
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Department of Physiology, Loma Linda University School of Medicine, California 92350. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Altitude* Animals Anoxia / etiology*, physiopathology* Blood Vessels / drug effects, metabolism, pathology Calcimycin / pharmacology Cerebrovascular Circulation* Female Penicillamine / analogs & derivatives, pharmacology Pregnancy Pregnancy Complications* S-Nitroso-N-Acetylpenicillamine Sheep Vasoconstriction Vasodilation |
| Grant Support | |
ID/Acronym/Agency:
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HD-03807/HD/NICHD NIH HHS; HL-41347/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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52-67-5/Penicillamine; 52665-69-7/Calcimycin; 79032-48-7/S-Nitroso-N-Acetylpenicillamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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