Document Detail


Pregnancy after renal transplantation--a five-yr single-center experience.
MedLine Citation:
PMID:  17488376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There has been an increase in the number of pregnancies in renal transplant recipients. Our aim was to report our experience with a significant casuistic. METHODS: Fifty-two pregnancies in 52 patients (January 2001 to December 2005), with two patients having a multiple pregnancy, were evaluated and patients were characterized and evaluated as clinical and obstetrical and perinatal outcomes. RESULTS: Mean patient age was 26.5 yr (range 17-38) with live donors in 34 (65.4%) and cadaver donors in 18 (34.6%). The mean transplantation-pregnancy interval was 3.1 yr. Calcineurin inhibitors (cyclosporine or tacrolimus) comprised the immunosuppressive therapy in 49 pregnancies (94.2%). Pregnancy complications were chronic hypertension in 33 patients (63.5%), anemia in 31 (59.6%), urinary tract infection in 22 (42.3%) and diabetes in four (7.7%). Nine patients (17.3%) received blood transfusion. Preeclampsia was diagnosed in 16 cases (30.7%) and renal dysfunction in 23 (44.2%) with preeclampsia assumed to be the main cause. One patient (1.9%) had graft loss, as a result of hemorrhagic shock after preterm delivery at home. Premature rupture of membranes occurred in four cases (7.7%), and preterm delivery in 20 (38.4%). Sixteen (29.6%) newborn were small for gestational age. One case of neonatal death was registered as a result of excessive prematurity. Cesarean section was performed in 32 patients (61.5%), the main indications being related to hypertension syndromes and fetal distress. CONCLUSIONS: This group of patients is characterized by a wide range of antenatal and perinatal problems and must be managed in specialized tertiary units to achieve the very best results.
Authors:
Leandro G Oliveira; Nelson Sass; Jussara L Sato; Kikumi S Ozaki; Jose O Medina Pestana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical transplantation     Volume:  21     ISSN:  0902-0063     ISO Abbreviation:  Clin Transplant     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-05-09     Completed Date:  2007-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  IM    
Affiliation:
Obstetrics Department, Federal University of Sao Paulo, Sao Paulo, Brazil. leminas@ig.com.br
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cesarean Section / statistics & numerical data
Female
Humans
Immunosuppressive Agents / therapeutic use
Kidney Transplantation*
Postoperative Period
Pregnancy
Pregnancy Complications / epidemiology
Pregnancy Outcome*
Pregnancy, High-Risk*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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