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Pregnancy after rebiopsy and vitrification of blastocysts following allele dropout after day 3 biopsy.
MedLine Citation:
PMID:  20951376     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To report a clinical pregnancy after rebiopsy and vitrification of blastocysts following allele dropout (ADO) of biopsied day 3 embryos.
DESIGN: Case report.
SETTING: Private center.
PATIENT(S): Thirty-year-old woman and her 33-year-old husband who carries the single-gene condition paraganglioma.
INTERVENTION(S): In vitro fertilization with day 3 embryo biopsy-ET-blastocyst biopsy and vitrification-subsequent frozen ET cycle.
MAIN OUTCOME MEASURE(S): Results from preimplantation genetic diagnosis and pregnancy results after fresh and frozen ETs.
RESULT(S): Nineteen oocytes were retrieved of which 13 were mature and 12 fertilized. Eleven embryos were biopsied on day 3: two were normal, five were affected, and four exhibited ADO. The two normal blastocysts were transferred, and three of the ADO blastocysts were biopsied and sent for reanalysis. The biopsied blastocysts were vitrified. No pregnancy resulted from the fresh ET. One of the biopsied blastocysts was normal, one received no result, and one exhibited ADO. A singleton clinical pregnancy resulted from a subsequent frozen ET of the thawed biopsied normal blastocyst.
CONCLUSION(S): Rebiopsy and vitrification of blastocysts could be used in cases of ADO or lack of results after day 3 embryo biopsy.
Authors:
J David Wininger; Tyl H Taylor; John J Orris; Michael Glassner; Sharon H Anderson
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Publication Detail:
Type:  Journal Article     Date:  2010-10-16
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1122.e1-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Main Line Fertility and Reproductive Medicine, Bryn Mawr, Pennsylvania.
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