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Pregnancy after adolescent and adult cancer: A population-based matched cohort study.
MedLine Citation:
PMID:  21387311     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Despite fertility-preserving initiatives, postcancer reproduction is expected to be lower than in the general population. Using data from the Cancer Registry and the Medical Birth Registry of Norway, postcancer pregnancy rates were analyzed in 27,556 survivors, and compared with those from a matched comparison group ("controls") from the general population. All were born after 1950, diagnosed from 1967-2004 at age 16-45, and had an observation time from the date of diagnosis (assigned date for controls), until pregnancy, death, age 46, or December 31 2006. Cox regression was used to estimate pregnancy rates, after adjusting for educational level, parity, and diagnostic period. Overall, cancer survivors had a lower pregnancy rate than the controls, but the rate for survivors was higher in males than in females (HR=0.74 [95% CI 0.71-0.78] and HR=0.61 [95% CI 0.58-0.64], respectively). However, the rates did not differ between controls and survivors of malignant melanoma or thyroid cancer. By contrast, the lowest HRs for pregnancy occurred in survivors of leukemia, cervical, or breast cancer. Increased pregnancy rates during the study period were detected for ovarian cancer (HR=0.2 [95% CI 0.1-0.3] to HR=0.7 [95% CI 0.5-0.9]), testicular cancer (HR=0.6 [95% CI 0.4-0.9] to HR=0.8 [95% CI 0.7-0.8]), and Hodgkin lymphoma diagnosed in men (HR=0.7 [95% CI 0.5-0.9] to HR=0.9 [95% CI 0.7-1.0]). In summary, fertility-preserving attempts have succeeded in patients with ovarian or testicular cancer and in males with Hodgkin lymphoma. Male survivors initiated pregnancies in a higher degree than female survivors.
Authors:
Hanne Stensheim; Milada Cvancarova; Bjørn Møller; Sophie D Fosså
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 UICC.
Affiliation:
Dept. of Clinical and Registry-based Research, Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway. hanne.stensheim@kreftregisteret.no.
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