Document Detail

Pregnancy after ICSI with ejaculated immotile spermatozoa from a patient with immotile cilia syndrome: a case report and review of the literature.
MedLine Citation:
PMID:  15670417     Owner:  NLM     Status:  MEDLINE    
This study presents a case of intracytoplasmic sperm injection (ICSI) with ejaculated immotile spermatozoa from a patient with immotile cilia syndrome. Semen analysis of the patient suffering from immotile cilia syndrome revealed an extreme oligoasthenoteratozoospermia (OAT: count <1.4 x 10(6)/ml, 0% motility and 3% normal morphology). Electron microscopy of sperm flagella showed the absence of inner and outer dynein arms. During the ICSI cycle, the hypo-osmotic swelling test (HOS) was used for the identification of viable spermatozoa in the pool of immotile spermatozoa for ICSI. A normal fertilization rate was found in eight out of the 12 oocytes. A first fresh double embryo transfer resulted in a late miscarriage at 21 weeks. A second healthy singleton pregnancy occurred after transfer of two frozen-thawed embryos from the same ICSI procedure. Although only one successful ICSI case of the immotile cilia syndrome combined with HOS is described here, HOS might be a simple but valuable tool to obtain normal fertilization and pregnancy for patients suffering from immotile spermatozoa.
Karen Peeraer; Martine Nijs; Dominique Raick; Willem Ombelet
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  9     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-26     Completed Date:  2005-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  659-63     Citation Subset:  IM    
Genk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium.
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MeSH Terms
Ciliary Motility Disorders / complications,  pathology,  physiopathology*
Oligospermia / complications,  pathology,  physiopathology
Severity of Illness Index
Sperm Count
Sperm Injections, Intracytoplasmic*
Sperm Motility
Spermatozoa / metabolism,  pathology,  ultrastructure

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