Document Detail

Pregnancy accounts for most of the gender difference in prevalence of familial RLS.
MedLine Citation:
PMID:  19592302     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was designed to evaluate the associated risk of RLS with pregnancy in relation to the family history and the age of symptom onset of RLS.
METHODS AND SUBJECTS: Data from a prior RLS family history study in which 1019 subjects (527 males, 492 females) were interviewed, provided a diagnosis and characterization of RLS and determination of pregnancy status on which the current study analysis was undertaken.
RESULTS: In the family members of RLS probands, the prevalence of RLS was significantly higher for parous women than for nulliparous women (49.5% vs. 33.7%, OR=1.92, 95% CI=1.16-3.19) or for men (49.5% vs. 30.0%, OR 2.29, 1.69-3.10), but no different for nulliparous women compared to men (33.7% vs. 30.0%, OR 1.19, 0.72-1.96). When only those whose RLS started at or after age 30 were considered, similar differences occurred. These differences were not observed among family members of control probands.
CONCLUSIONS: These data indicate pregnancy has a major impact on the risk of developing RLS for those with a family history of RLS. This pregnancy effect appears to account for most of the gender differences often reported in overall RLS prevalence data.
Nicholas P Pantaleo; Wayne A Hening; Richard P Allen; Christopher J Earley
Publication Detail:
Type:  Journal Article     Date:  2009-07-09
Journal Detail:
Title:  Sleep medicine     Volume:  11     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-24     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  310-3     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Dept. of Psychology and Brain Science, Johns Hopkins Univ., Baltimore, MD, USA.
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MeSH Terms
Age Factors
Age of Onset
Middle Aged
Restless Legs Syndrome / epidemiology*,  etiology,  genetics
Risk Factors
Sex Factors
Grant Support
R01 AG016362-01A2/AG/NIA NIH HHS

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