| Pregnancy accounts for most of the gender difference in prevalence of familial RLS. | |
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MedLine Citation:
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PMID: 19592302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was designed to evaluate the associated risk of RLS with pregnancy in relation to the family history and the age of symptom onset of RLS. METHODS AND SUBJECTS: Data from a prior RLS family history study in which 1019 subjects (527 males, 492 females) were interviewed, provided a diagnosis and characterization of RLS and determination of pregnancy status on which the current study analysis was undertaken. RESULTS: In the family members of RLS probands, the prevalence of RLS was significantly higher for parous women than for nulliparous women (49.5% vs. 33.7%, OR=1.92, 95% CI=1.16-3.19) or for men (49.5% vs. 30.0%, OR 2.29, 1.69-3.10), but no different for nulliparous women compared to men (33.7% vs. 30.0%, OR 1.19, 0.72-1.96). When only those whose RLS started at or after age 30 were considered, similar differences occurred. These differences were not observed among family members of control probands. CONCLUSIONS: These data indicate pregnancy has a major impact on the risk of developing RLS for those with a family history of RLS. This pregnancy effect appears to account for most of the gender differences often reported in overall RLS prevalence data. |
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Authors:
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Nicholas P Pantaleo; Wayne A Hening; Richard P Allen; Christopher J Earley |
Publication Detail:
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Type: Journal Article Date: 2009-07-09 |
Journal Detail:
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Title: Sleep medicine Volume: 11 ISSN: 1878-5506 ISO Abbreviation: Sleep Med. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-05-24 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 100898759 Medline TA: Sleep Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 310-3 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Dept. of Psychology and Brain Science, Johns Hopkins Univ., Baltimore, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Age of Onset Aged Family Female Humans Male Middle Aged Pregnancy Prevalence Restless Legs Syndrome / epidemiology*, etiology, genetics Risk Factors Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG016362-01A2/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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