| Pregnancy Outcomes in Systemic Lupus Erythematosus with and without Previous Nephritis. | |
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MedLine Citation:
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PMID: 21632681 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To compare rates and predictors of pregnancy complications in mothers with systemic lupus erythematosus (SLE) with and without previous nephritis (PN). METHODS: Retrospective analysis of 107 pregnancies in 83 women with SLE diagnosed prepregnancy. RESULTS: Mothers with PN had higher rates of preterm delivery (< 37/40, 30% vs 11%, p = 0.029) than those without PN. Women with PN had earlier onset of preeclampsia [median 34.5 weeks (IQR 32-37) vs 37.5 weeks (IQR 35-38, p = 0.047)] that was more frequently complicated by preterm delivery (p = 0.02). Risk factors for preeclampsia in women with PN include 10-13 weeks' gestation diastolic blood pressure > 80 mmHg and proteinuria, and prepregnancy estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73 m2. In women with PN, midtrimester uterine-artery-Doppler notching had low negative predictive value (47%). After 39 months followup, eGFR was stable in women with or without PN. CONCLUSION: In SLE, preterm deliveries are more frequent and preeclampsia occurs earlier in women with PN, but longterm eGFR is preserved. |
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Authors:
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Kate Bramham; Beverley J Hunt; Susan Bewley; Sarah Germain; Irene Calatayud; Munther A Khamashta; Catherine Nelson-Piercy |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
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Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From King's College London; Women's Health Directorate and Louise Coote Lupus Unit; Guy's and St. Thomas' NHS Foundation Trust; St. Thomas Hospital Lupus Research Unit, The Rayne Institute, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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