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Pregnancy Outcome after in-utero Exposure to Angiotensin Converting Enzyme Inhibitors or Angiotensin Receptor Blockers.
MedLine Citation:
PMID:  21338666     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To examine first trimester safety of angiotensin-converting-enzyme-inhibitors (ACEIs) or angiotensin-receptor-blockers (ARBs). Study Design: Prospective observational cohort regarding pregnancy ACEI/ARBs-exposure including contacts to two Teratology Information Services in Israel (1994-2007) and Italy (1990-2008), with two comparison groups: 1. exposed to other anti-hypertensives (OAH) 2. after non-teratogenic exposure (NTE) in similar time frames. Results: 252 ACEI/ARBs-exposed, 256 OAH-exposed and 495 NTE-exposed pregnancies were followed-up. The rate of major congenital anomalies was comparable between the groups (8/190, 4.2%, ACEI/ARB; 9/212, 4.2%, OAH; 18/471, 3.8% NTE; p=0.954) among first trimester exposed pregnancies. The median gestational age at delivery was two weeks earlier, rate of preterm deliveries more than two-fold higher, and median birth weight more than 200g lower in the ACEI/ARB and OAH groups compared to the NTE group. Conclusion: The present study suggests that ACEI/ARBs are not major teratogens when used in the first trimester, and can reassure women with similar exposures.
Authors:
Orna Diav-Citrin; Svetlana Shechtman; Yehudit Halberstadt; Victoriya Finkel-Pekarsky; Rebecka Wajnberg; Judy Arnon; Elena Di Gianantonio; Maurizio Clementi; Asher Ornoy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-18
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  -     ISSN:  1873-1708     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
The Israeli Teratology Information Service, Jerusalem, Israel Ministry of Health.
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