Document Detail


Pregnancy is Not Detrimental to the Melanoma Patient with Clinically Localized Disease.
MedLine Citation:
PMID:  20725540     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: There exists a strong belief among physicians and the lay public that pregnancy adversely affects survival in patients with melanoma. The authors asked if there was any evidence to support this in patients with clinically localized disease.
METHODS: The authors reviewed the published literature on MEDLINE.
RESULTS: The authors found no compelling evidence in the literature that pregnancy has a negative impact on survival in patients with clinically localized cutaneous melanoma. Two recent population-based studies reported no negative impact of pregnancy on survival when pregnant melanoma patients were compared to nonpregnant gender-matched controls. A small increased risk of cause-specific death was noted in a recent population-based study, though this effect was small (HR, 1.52, p=0.47) and pregnant patients were more likely to have axial primary sites, which are associated with a poorer outcome.
CONCLUSION: There is no compelling evidence that pregnancy adversely affects outcome in melanoma patients who have clinically localized disease. Continuing to recommend a delay in childbearing for these patients is not supported by the published medical literature.
Authors:
Mary S Brady; Nikki S Noce
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical and aesthetic dermatology     Volume:  3     ISSN:  1941-2789     ISO Abbreviation:  J Clin Aesthet Dermatol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2011-07-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101518173     Medline TA:  J Clin Aesthet Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-8     Citation Subset:  -    
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