Document Detail

Pregnancy and Multiple Sclerosis (MS): A Beneficial Association. Possible therapeutic application of embryo-specific Pre-implantation Factor (PIF*).
MedLine Citation:
PMID:  22805418     Owner:  NLM     Status:  Publisher    
A typical autoimmune neuro-inflammatory disease (NID), multiple sclerosis (MS), is more prevalent in women than in men. Majority of patients with MS are of child-bearing age; therefore, occurrence in pregnancy is common. Herein, we review proposed disease mechanisms and suggest therapeutic interventions, focusing on the remarkable pregnancy-induced protection against MS - insofar considered as best, albeit temporary therapy for such harsh NID. Current drugs used for MS therapy in pregnancy are described. Role of non-pregnancy-specific agents considered involved in amelioration of disease is also presented. This review highlights pregnancy-derived neuro-protective agents, proposing that unique pregnancy-induced immune-protective environment is because of the conceptus and its direct action. The essential role of pre-implantation factor (PIF) in pregnancy is delineated. Finally, PIF immune-modulatory effects and efficacy in chronic model of neuro-inflammation to reduce inflammation and paralysis coupled with neural regeneration is presented. Overall, we postulate that this embryo-derived-compound holds great promise to improve MS and possibly neuro-inflammation in general.
Michael J Paidas; Jack Annunziato; Michael Romano; Lola Weiss; Reuven Or; Eytan R Barnea
Related Documents :
10328868 - Administration of recombinant human stem cell factor (rhscf) and granulocyte-colony sti...
105688 - Female homosexual behavior in macaca mulatta.
22132888 - Pregnancy-associated diseases are characterized by the composition of the systemic regu...
22197628 - Placental characteristics in growth-discordant monochorionic twins: a matched case-cont...
16594548 - Increased plasma mrnas of placenta-specific 1 (plac1) and glial cells-missing 1 (gcm1) ...
3934658 - Comparative study of 15 lysosomal enzymes in chorionic villi and cultured amniotic flui...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Yale Women and Children's Center for Blood Disorders, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regenerative Medicine for the Treatment of Spinal Cord Injury: More than Just Promises?
Next Document:  Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin...