| Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids. | |
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MedLine Citation:
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PMID: 20850520 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Chlorination of drinking water yields hundreds of disinfection by-products (DBPs). Among the DBPs, four trihalomethanes (THMs; chloroform, bromodichloromethane, chlorodibromomethane, bromoform) and five haloacetic acids (HAAs; chloroacetic, dichloroacetic, trichloroacetic, bromoacetic, and dibromoacetic acid) are U.S. EPA regulated. We assessed the combined toxicity of these DBPs. F344 rats were treated with mixtures of the four THMs (THM4), the five HAAs (HAA5), or nine DBPs (DBP9; THM4+HAA5). Mixtures were administered in 10% Alkamuls(®) EL-620 daily by gavage on gestation days 6-20. Litters were examined postnatally. All three mixtures caused pregnancy loss at ≥613μmol/kg/day. In surviving litters, resorption rates were increased in groups receiving HAA5 at 615μmol/kg/day and DBP9 at 307μmol/kg/day. HAA5 caused eye malformations (anophthalmia, microphthalmia) at ≥308μmol/kg/day. Thus, both HAAs and THMs contributed to DBP9-induced pregnancy loss. The presence of THMs in the full mixture, however, appeared to reduce the incidence of HAA-induced eye defects. |
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Authors:
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Michael G Narotsky; Deborah S Best; Anthony McDonald; Elizabeth A Godin; E Sidney Hunter; Jane Ellen Simmons |
Publication Detail:
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Type: Journal Article Date: 2010-09-17 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 31 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 59-65 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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