Document Detail

Pregnancy and laboratory studies: a reference table for clinicians.
MedLine Citation:
PMID:  19935037     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To establish normal reference ranges during pregnancy for common laboratory analytes. DATA SOURCES: We conducted a comprehensive electronic database review using PUBMED and MEDLINE databases. We also reviewed textbooks of maternal laboratory studies during uncomplicated pregnancy. METHODS OF STUDY SELECTION: We searched the databases for studies investigating various laboratory analytes at various times during pregnancy. All abstracts were examined by two investigators and, if they were found relevant, the full text of the article was reviewed. Articles were included if the analyte studied was measured in pregnant women without major medical problems or confounding conditions and if the laboratory marker was measured and reported for a specified gestational age. TABULATION, INTEGRATION, AND RESULTS: For each laboratory marker, data were extracted from as many references as possible, and these data were combined to establish normal reference ranges in pregnancy. When possible, the 2.5 and 97.5 percentiles were reported as the normal range. In some of the reference articles, however, the reported range was based on the minimum and maximum value of the laboratory constituent. In those cases, the minimum to maximum range was used and combined with the 2.5 and 97.5 percentile range. We found that there is a substantial difference in normal values in some laboratory markers in the pregnant state when compared with the nonpregnant state. CONCLUSION: It is important to consider normal reference ranges specific to pregnancy when interpreting some laboratory results that may be altered by the normal changes of pregnancy.
Mina Abbassi-Ghanavati; Laura G Greer; F Gary Cunningham
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  114     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2009-12-21     Revised Date:  2010-03-29    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1326-31     Citation Subset:  AIM; IM    
University of Texas Southwestern Medical Center, Dallas, Texas 75390;, USA.
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MeSH Terms
Pregnancy / blood*
Reference Values
Statistics as Topic
Comment In:
Obstet Gynecol. 2010 Apr;115(4):868; author reply 868-9   [PMID:  20308857 ]
Erratum In:
Obstet Gynecol. 2010 Feb;115(2 Pt 1):387

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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