Document Detail


Pregnancy Influences the Antibody Response to Trivalent Influenza Immunization.
MedLine Citation:
PMID:  22984116     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report the immunogenicity of trivalent influenza immunization in 29 pregnant compared to 22 non-pregnant women. We obtained blood on day 0 prior to 2011-2012 influenza vaccine administration, and day 28 post-immunization. Hemagglutination inhibition (HAI) geometric mean titers were similar before immunization but were significantly reduced by 40% to 50% in pregnant women post-immunization for A/California (H1N1) (p=0.027) and A/Perth (H3N2) (p=0.037). Post-immunization HAI titers were similar between groups for B/Brisbane (p=0.390). The geometric mean ratio (fold rise) for H1N1 was non-significantly reduced in pregnant participants (p=0.089). The percent of participants who seroconverted and achieved seroprotection were similar between groups.
Authors:
Elizabeth P Schlaudecker; Monica M McNeal; Caitlin N Dodd; Joseph B Ranz; Mark C Steinhoff
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-14
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Infectious Diseases, Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
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