Document Detail

Pregnancy disorders appear to modify the risk for retinopathy of prematurity associated with neonatal hyperoxemia and bacteremia.
MedLine Citation:
PMID:  23297684     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore (1) whether extremely low gestational age newborns exposed to inflammation-associated pregnancy disorders differ in retinopathy of prematurity (ROP) risk from infants exposed to placenta dysfunction-associated disorders, and (2) whether ROP risk associated with postnatal hyperoxemia and bacteremia differs among infants exposed to these disorders.
METHODS: Pregnancy disorders resulting in preterm birth include inflammation-associated: preterm labor, prelabor premature rupture of membranes (pPROM), cervical insufficiency, and abruption and placenta dysfunction-associated: preeclampsia and fetal indication. The risk of severe ROP associated with pregnancy disorders was evaluated by multivariable analyses in strata defined by potential effect modifiers, postnatal hyperoxemia and bacteremia.
RESULTS: Compared to preterm labor, infants delivered after pPROM were at reduced risk of plus disease (Odds ratio = 0.4, 95% confidence interval: 0.2-0.8) and prethreshold/threshold ROP (0.5, 0.3-0.8). Infants delivered after abruption had reduced risk of zone I ROP (0.2, 0.1-0.8) and prethreshold/threshold ROP (0.3, 0.1-0.7). In stratified analyses, infants born after placenta dysfunction had higher risks of severe ROP associated with subsequent postnatal hyperoxemia and bacteremia than infants born after inflammation-associated pregnancy disorders.
CONCLUSION: Infants exposed to placenta dysfunction have an increased risk of severe ROP following postnatal hyperoxemia and bacteremia compared to infants exposed to inflammation-associated pregnancy disorders.
Jennifer W Lee; Thomas McElrath; Minghua Chen; David K Wallace; Elizabeth N Allred; Alan Leviton; Olaf Dammann
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2013-02-14
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  26     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2014-01-27     Revised Date:  2014-10-02    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  811-8     Citation Subset:  IM    
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MeSH Terms
Bacteremia / epidemiology*
Delivery, Obstetric
Hyperoxia / epidemiology*
Infant, Extremely Premature
Infant, Newborn
Pregnancy Complications / epidemiology*
Retinopathy of Prematurity / epidemiology*
United States / epidemiology
Grant Support
1R21EY019253-01/EY/NEI NIH HHS; 2R01NS040069-06A2/NS/NINDS NIH HHS; 5U01NS040069-05S1/NS/NINDS NIH HHS; P30 HD018655/HD/NICHD NIH HHS; P30-HD-18655/HD/NICHD NIH HHS; R21 EY019253/EY/NEI NIH HHS; U01 NS040069/NS/NINDS NIH HHS

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