Document Detail

Pregnancy and Cushing's syndrome: example of endocrine interaction.
MedLine Citation:
PMID:  3281917     Owner:  NLM     Status:  MEDLINE    
Pregnancy rarely occurs in women with Cushing's syndrome, and when it does, fetal mortality and morbidity are very high. We describe a 30-year-old woman who was found to have severe Cushing's syndrome in the 22nd week of her first pregnancy, after a year of unsuccessful attempts to conceive. The patient had the majority of the symptoms and signs characteristic of the syndrome. Laboratory examinations revealed hypokalemia of 2.7 mEq/l, serum cortisol 39.5 micrograms/dl without diurnal variation, free urinary cortisol 1,850 to 3,500 micrograms/24 h, 17-hydroxycorticosteroids (OHCS) 52.5 mg/24 h, 17-ketosteroids (KS) 12 mg/24 h, and ACTH 29 pg/ml. No suppression was observed upon dexamethasone administration (2 and 8 mg). Ultrasound examination of the adrenal glands revealed a left adrenal tumor with a diameter of 4.2 cm. An adrenocortical adenoma was successfully excised in the 24th week of pregnancy. During the 37th week of pregnancy, she delivered a normal baby girl. Postoperatively, the patient was put on maintenance therapy. One year after delivery, mother and child are in perfect health.
E Barasch; M Sztern; S Spinrad; R Chayen; C Servadio; H Kaufman; M Ben Bassat; I Blum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  24     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  101-4     Citation Subset:  IM    
Department of Medicine C, Rokach (Hadassah) Hospital, Tel Aviv, Israel.
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MeSH Terms
Adenoma / complications,  surgery
Adrenal Cortex Hormones / blood
Adrenal Cortex Neoplasms / complications,  surgery
Cushing Syndrome / diagnosis*,  therapy
Infant, Newborn
Pregnancy Complications / diagnosis*
Pregnancy Trimester, Third
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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