| Pregnancy and Cushing's syndrome: example of endocrine interaction. | |
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MedLine Citation:
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PMID: 3281917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy rarely occurs in women with Cushing's syndrome, and when it does, fetal mortality and morbidity are very high. We describe a 30-year-old woman who was found to have severe Cushing's syndrome in the 22nd week of her first pregnancy, after a year of unsuccessful attempts to conceive. The patient had the majority of the symptoms and signs characteristic of the syndrome. Laboratory examinations revealed hypokalemia of 2.7 mEq/l, serum cortisol 39.5 micrograms/dl without diurnal variation, free urinary cortisol 1,850 to 3,500 micrograms/24 h, 17-hydroxycorticosteroids (OHCS) 52.5 mg/24 h, 17-ketosteroids (KS) 12 mg/24 h, and ACTH 29 pg/ml. No suppression was observed upon dexamethasone administration (2 and 8 mg). Ultrasound examination of the adrenal glands revealed a left adrenal tumor with a diameter of 4.2 cm. An adrenocortical adenoma was successfully excised in the 24th week of pregnancy. During the 37th week of pregnancy, she delivered a normal baby girl. Postoperatively, the patient was put on maintenance therapy. One year after delivery, mother and child are in perfect health. |
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Authors:
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E Barasch; M Sztern; S Spinrad; R Chayen; C Servadio; H Kaufman; M Ben Bassat; I Blum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Israel journal of medical sciences Volume: 24 ISSN: 0021-2180 ISO Abbreviation: Isr. J. Med. Sci. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-05-26 Completed Date: 1988-05-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0013105 Medline TA: Isr J Med Sci Country: ISRAEL |
Other Details:
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Languages: eng Pagination: 101-4 Citation Subset: IM |
Affiliation:
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Department of Medicine C, Rokach (Hadassah) Hospital, Tel Aviv, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications,
surgery Adrenal Cortex Hormones / blood Adrenal Cortex Neoplasms / complications, surgery Adrenalectomy Adult Cushing Syndrome / diagnosis*, therapy Female Humans Infant, Newborn Pregnancy Pregnancy Complications / diagnosis* Pregnancy Trimester, Third Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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