Document Detail

Prefrontal neurons coding suppression of specific saccades.
MedLine Citation:
PMID:  15294148     Owner:  NLM     Status:  MEDLINE    
The prefrontal cortex has been implicated in the suppression of unwanted behavior, based upon observations of humans and monkeys with prefrontal lesions. Despite this, there has been little direct neurophysiological evidence for a mechanism that suppresses specific behavior. In this study, we used an oculomotor delayed match/nonmatch-to-sample task in which monkeys had to remember a stimulus location either as a marker of where to look or as a marker of where not to look. We found a group of neurons in both the frontal eye field and the caudal prefrontal cortex that carried signals selective for the forbidden stimulus. The activity of these "don't look" neurons correlated with the monkeys' success or failure on the task. These results demonstrate a frontal signal that is related to the active suppression of one action while the subject performs another.
Ryohei P Hasegawa; Barry W Peterson; Michael E Goldberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  43     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-05     Completed Date:  2004-11-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-25     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Cell Press
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MeSH Terms
Action Potentials / physiology
Macaca mulatta
Memory / physiology
Neurons / physiology*
Photic Stimulation / methods
Prefrontal Cortex / physiology*
Reaction Time / physiology*
Saccades / physiology*
Grant Support
P30 EY019007/EY/NEI NIH HHS; R01 EY017039/EY/NEI NIH HHS
Comment In:
Neuron. 2004 Aug 5;43(3):297-9   [PMID:  15294137 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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