Document Detail

Prefrontal dopamine efflux during exposure to drug-associated contextual cues in rats with prior repeated methamphetamine.
MedLine Citation:
PMID:  17208653     Owner:  NLM     Status:  MEDLINE    
Conditioned stimulus-reward response and prefrontal dopamine efflux under context previously paired with methamphetamine administration were assessed in rats with or without prior sensitizing regimen. Sensitizing pretreatment was administered with methamphetamine (1mg/kg, every other day for six sessions) for behavioral sensitization. The animals received methamphetamine (1mg/kg) or saline injection (each for six sessions) to pair with distinct contexts on alternate days to induce conditioned place preference. Then, dopamine outflows in the medial prefrontal cortex were analyzed on the next day via microdialysis study as animals exposed to the methamphetamine or saline-paired context, respectively. Prefrontal DA efflux increased in those rats without sensitizing pretreatment, while they occupied the methamphetamine-paired chamber. The rats with prior sensitizing regimen demonstrated more robust conditioned place preference than those without pretreatment, however, their dopamine efflux was attenuated, while remaining in methamphetamine-paired context. It is suggested that the attenuated responsiveness of mesocortical dopamine transmission in prior sensitized rats may, at least in part, be responsible for their augmented conditioned place preference, which resulted from activation of related brain areas that together strengthen the associative learning to drug-related stimuli. This paradigm may reflect a dysregulated prefrontal function in the methamphetamine abusers.
Shi-Kwang Lin; Wynn H T Pan; Pen-Ho Yeh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-30
Journal Detail:
Title:  Brain research bulletin     Volume:  71     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Institute of Pharmacology, National Yang-Ming University, 155, Section 2 Li-Noon Street, Taipei 112, Taiwan, ROC.
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MeSH Terms
Central Nervous System Stimulants / pharmacology*
Chromatography, High Pressure Liquid
Conditioning, Operant / drug effects
Data Interpretation, Statistical
Dopamine / metabolism*
Methamphetamine / pharmacology*
Motor Activity / drug effects
Prefrontal Cortex / metabolism*
Rats, Sprague-Dawley
Synaptic Transmission / drug effects
Reg. No./Substance:
0/Central Nervous System Stimulants; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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