Document Detail


Prefrontal cortex controls human balance during overground ataxic gait.
MedLine Citation:
PMID:  22751355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: 1) to verify if prefrontal cortex (PFC) is activated during over ground walking in ataxic patients, 2) to correlate the clinical parameters of gait with the PFC activation patterns.
METHODS: Fourteen patients and 20 healthy subjects were studied. Ataxia was assessed by the Scale for the Assessment and Rating of Ataxia (SARA). A 2-channel near-infrared system was used to investigate the changes in oxygenated ([O2Hb]t) and deoxygenated ([HHb]t) hemoglobin concentrations on the PFC during gait. [O2Hb] baseline-corrected activation values ([O2Hb]c) were calculated by the difference between [O2Hb]t and [O2Hb] during upright posture ([O2Hb]b).
RESULTS: [O2Hb]t was increased for both channels (respectively p < 0.01 and p = 0.01) only in the patients. No variation was observed in [HHB]t. The correlation coefficient between [O2Hb]c and the SARA gait score was respectively r: 0.878 (p < 0.01) and r: 0.839 (p < 0.01) for the right and left PFC, between [O2Hb]c and the SARA stance score respectively r: 0.893 (p < 0.01) and r: 0.832 (p < 0.01).
CONCLUSIONS: During over ground gait PFC is bilaterally activated in patients with severe chronic ataxia. These findings may be associated with compensatory mechanisms which are involved in severe conditions when other nervous centers controlling balance are functionally not efficient.
Authors:
Pietro Caliandro; Marcella Masciullo; Luca Padua; Chiara Simbolotti; Gabriele Di Sante; Giuseppina Russo; Claudia Garattini; Gabriella Silvestri; Paolo M Rossini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Restorative neurology and neuroscience     Volume:  30     ISSN:  1878-3627     ISO Abbreviation:  Restor. Neurol. Neurosci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-02-06     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  9005499     Medline TA:  Restor Neurol Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  397-405     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy. p.caliandro@rm.unicatt.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Gait Ataxia / pathology*,  physiopathology*
Hemoglobins / metabolism
Humans
Male
Middle Aged
Oxyhemoglobins / metabolism
Postural Balance / physiology*
Posture / physiology*
Prefrontal Cortex / metabolism,  physiopathology*
Spectroscopy, Near-Infrared
Statistics as Topic
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 9008-02-0/deoxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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