Document Detail

Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging.
MedLine Citation:
PMID:  23354332     Owner:  NLM     Status:  MEDLINE    
Aging has independently been associated with regional brain atrophy, reduced slow wave activity (SWA) during non-rapid eye movement (NREM) sleep and impaired long-term retention of episodic memories. However, whether the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. We found that age-related medial prefrontal cortex (mPFC) gray-matter atrophy was associated with reduced NREM SWA in older adults, the extent to which statistically mediated the impairment of overnight sleep-dependent memory retention. Moreover, this memory impairment was further associated with persistent hippocampal activation and reduced task-related hippocampal-prefrontal cortex functional connectivity, potentially representing impoverished hippocampal-neocortical memory transformation. Together, these data support a model in which age-related mPFC atrophy diminishes SWA, the functional consequence of which is impaired long-term memory. Such findings suggest that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age-related cognitive decline in later life.
Bryce A Mander; Vikram Rao; Brandon Lu; Jared M Saletin; John R Lindquist; Sonia Ancoli-Israel; William Jagust; Matthew P Walker
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-27
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-04-09     Revised Date:  2014-10-02    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / pathology*,  physiology,  psychology
Atrophy / pathology,  physiopathology,  psychology
Brain Mapping
Brain Waves / physiology*
Hippocampus / pathology*,  physiology
Image Processing, Computer-Assisted
Memory / physiology*
Memory, Episodic
Neuropsychological Tests
Organ Size
Prefrontal Cortex / pathology*,  physiology
Sleep / physiology*
Young Adult
Grant Support
F32-AG039170/AG/NIA NIH HHS; R01 AG031164/AG/NIA NIH HHS; R01-AG031164/AG/NIA NIH HHS; R01-AG034570/AG/NIA NIH HHS; R01-AG08415/AG/NIA NIH HHS

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