| Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. | |
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MedLine Citation:
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PMID: 23354332 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aging has independently been associated with regional brain atrophy, reduced slow wave activity (SWA) during non-rapid eye movement (NREM) sleep and impaired long-term retention of episodic memories. However, whether the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. We found that age-related medial prefrontal cortex (mPFC) gray-matter atrophy was associated with reduced NREM SWA in older adults, the extent to which statistically mediated the impairment of overnight sleep-dependent memory retention. Moreover, this memory impairment was further associated with persistent hippocampal activation and reduced task-related hippocampal-prefrontal cortex functional connectivity, potentially representing impoverished hippocampal-neocortical memory transformation. Together, these data support a model in which age-related mPFC atrophy diminishes SWA, the functional consequence of which is impaired long-term memory. Such findings suggest that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age-related cognitive decline in later life. |
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Authors:
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Bryce A Mander; Vikram Rao; Brandon Lu; Jared M Saletin; John R Lindquist; Sonia Ancoli-Israel; William Jagust; Matthew P Walker |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-27 |
Journal Detail:
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Title: Nature neuroscience Volume: - ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Sleep and Neuroimaging Laboratory, University of California, Berkeley, California, USA. |
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