Document Detail

Prefrontal Space Ratio: comparison between trisomy 21 and euploid fetuses in the second trimester.
MedLine Citation:
PMID:  22302766     Owner:  NLM     Status:  Publisher    
Objective: To evaluate a novel ultrasound measurement, the prefrontal space ratio (PFSR), in second-trimester trisomy 21 and euploid fetuses. Methods: Stored 3D volumes of fetal profiles from 26 trisomy 21 and 90 euploid fetuses at 15-25 weeks' gestation were examined. A line was drawn between the leading edge of the mandible and the maxilla (MM line) and extended in front of the forehead. The ratio of the distance between the leading edge of the skull and the leading edge of the skin (d1) to the distance between the skin and the point where the MM line was intercepted (d2) was calculated. The distributions of PFSR in trisomy 21 and euploid fetuses were compared. Results: The PFSR in trisomy 21 fetuses (mean 0.36, range 0 - 0.81) was significantly lower than in euploid fetuses (mean 1.48, range 0.85 - 2.95; p < 0.001). Conclusion: The PFSR appears to be a highly sensitive and specific marker of trisomy 21 in the second-trimester of pregnancy. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
J Sonek; F Molina; A K Hiett; M Glover; D McKenna; K H Nicolaides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Fetal Medicine Foundation USA, Dayton, OH, USA; Division of Maternal Fetal Medicine, Wright State University, Dayton, OH, USA.
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