Document Detail


Prefrontal N-acetylaspartate and poststroke recovery: a longitudinal proton spectroscopy study.
MedLine Citation:
PMID:  17353314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Functional imaging studies suggest that poststroke recovery is related to the reorganization in both contralesional and ipsilesional prefrontal cortex. Little is known, however, about how longitudinal metabolic changes in prefrontal regions relate to the improvement after stroke. We sought to determine whether poststroke recovery is associated with changes in N-acetylaspartate/creatine (NAA/Cr) ratio within contralesional prefrontal regions. MATERIALS AND METHODS: Twenty-seven patients with a first ischemic stroke located outside the frontal lobes were included. Proton MR spectroscopy ((1)H-MRS) was performed on a 1.5T scanner. Point-resolved spectroscopy sequence (PRESS) was used. NAA/Cr was measured both in ipsilesional and contralesional prefrontal regions in early (14 +/- 6 days after stroke) and chronic phases of the disease (110 +/- 30 days after). Patients' neurologic status was assessed using Scandinavian Stroke Scale (SSS) at discharge from the stroke unit and during second (1)H-MRS examination. RESULTS: Subjects showing increased contralesional NAA/Cr from first to follow-up examination improved significantly more on the SSS than patients not showing this increase. Analysis was performed while correcting for change in NAA/Cr levels in the ipsilesional hemisphere. For the whole group, the change in contralesional NAA/Cr was significantly correlated to the change in SSS scores (r = 0.40, P = .03). Change in the ipsilesional NAA/Cr measures did not correlate with the change in SSS scores. CONCLUSION: Poststroke recovery was related to the increase in contralesional prefrontal NAA/Cr. This association may reflect recovery mechanisms involving the nonaffected hemisphere. Further assessment of these regions may provide information about mechanisms contributing to neurologic improvement.
Authors:
L Glodzik-Sobanska; J Li; L Mosconi; A Slowik; J Walecki; A Szczudlik; B Sobiecka; M J de Leon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  28     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-13     Completed Date:  2007-04-18     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-4     Citation Subset:  IM    
Affiliation:
Center for Brain Health, New York University School of Medicine, New York, NY 10016-6481, USA. lidia.sobanska@med.nyu.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aspartic Acid / analogs & derivatives,  metabolism
Brain Ischemia / metabolism,  pathology
Creatine / metabolism
Female
Follow-Up Studies
Functional Laterality
Humans
Longitudinal Studies
Magnetic Resonance Spectroscopy*
Male
Middle Aged
Prefrontal Cortex / metabolism*,  pathology*
Protons
Recovery of Function*
Stroke / metabolism*,  pathology*
Chemical
Reg. No./Substance:
0/Protons; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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