Document Detail

Preformulation: effect of moisture content on microcrystalline cellulose (Avicel PH-302) and its consequences on packing performances.
MedLine Citation:
PMID:  10529895     Owner:  NLM     Status:  MEDLINE    
This study evaluates the influence of moisture content on the packing performances of a new grade of microcrystalline cellulose (MCC) (Avicel PH-302) either by classical method or by an unconventional compression technique (constant volume reduction of powder bed). An increase in moisture content decreases the apparent density of the powder bed, resulting from interparticulate friction enhancement. This modification of apparent density seems to be the main effect caused by the presence of humidity, which explains the variations of compression properties, like an increase of powder plasticity generally observed in the experimental conditions.
V Nicolas; O Chambin; C Andrès; M H Rochat-Gonthier; Y Pourcelot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  25     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-03     Completed Date:  1999-12-03     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1137-42     Citation Subset:  IM    
Technological Group on Pharmaceutical Powders, School of Pharmacy, University of Burgundy, Dijon, France.
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MeSH Terms
Cellulose / chemistry*
Chemistry, Pharmaceutical
Excipients / chemistry*
Plastics / chemistry
Stress, Mechanical
Water / chemistry*
Reg. No./Substance:
0/Excipients; 0/Plastics; 0/Powders; 0/Tablets; 0/microcrystalline cellulose; 7732-18-5/Water; 9004-34-6/Cellulose

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