| Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitisation studies in vivo and in vitro. | |
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MedLine Citation:
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PMID: 20586540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS: In vivo, the gadolinium chelate coating allows one to perform real-time Magnetic Resonance Imaging (MRI) pharmacokinetic analysis during intravenous infusion. Experiments were performed following treatment with 10 Gy of 150 kVp X-rays. In vitro experiments were also performed with clonogenic assays to generate dose response curves for the same cells. RESULTS: We observed a preferential accumulation of Au@DTDTPA:Gd in tumours; a substantial toxicity for tumour cells in vitro, but no obvious toxicity for mice; and the absence of a synergistic effect with Au@DTDTPA:Gd and radiation in all experiments. CONCLUSIONS: The additional absorption of radiation and the subsequent increase in secondary electrons, attributable to the presence of gold in Au@DTDTPA:Gd, does not lead to radiosensitisation. However, this chelating agent exhibits a chemotherapeutic action which warrants further investigation. When compared to positive results obtained by others on radiosensitisation by GNP, the present study suggests that the chemotherapeutic and radiosensitising properties of GNP may depend strongly on the nature of the coating. |
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Authors:
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Etienne M Hébert; Pierre-Jean Debouttière; Martin Lepage; Léon Sanche; Darel J Hunting |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation biology Volume: 86 ISSN: 1362-3095 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-08-25 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: England |
Other Details:
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Languages: eng Pagination: 692-700 Citation Subset: IM; S |
Affiliation:
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Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Female Gadolinium DTPA / pharmacokinetics*, pharmacology Gold / pharmacokinetics*, pharmacology Magnetic Resonance Imaging / methods* Mammary Neoplasms, Experimental / metabolism, mortality, radiotherapy* Mice Mice, Inbred BALB C Nanoparticles* Radiation-Sensitizing Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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81356//Canadian Institutes of Health Research; MOP 81356//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Radiation-Sensitizing Agents; 7440-57-5/Gold; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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