Document Detail


Preferential resynthesis of muscle glycogen in fasting rats after exhausting exercise.
MedLine Citation:
PMID:  6990793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite carbohydrate starvation (fasting or fat feeding) considerable glycogen accumulation, ranging from 20 to 30 mumol glucose/g, occurred in hindlimb muscles of rats following exhausting exercise that caused severe muscle and liver glycogen depletion and hypoglycemia. The largest increase in muscle glycogen occurred during the first 3 h after exercise when plasma levels of glucagon and epinephrine were very high and insulin concentration was low. The concentrations of glycogen attained in different hindlimb muscles in the fasting and fat-fed animals were between 50 and 100% of the values found in rats fed carbohydrate after the exhausting exercise. In rats fed carbohydrate following exercise, liver glycogen accumulation greatly exceeds muscle glycogen accumulation. A remarkable difference in the response of liver glycogen was seen in the carbohydrate starved rats. In contrast to the rapid increase in muscle glycogen, liver glycogen was still essentially completely depleted in the fasting and fat-fed rats 24 h after exercise. This indicates that the glucose made available via gluconeogenesis was preferentialy channeled away from liver glycogen synthesis into muscle glycogen.
Authors:
R D Fell; J A McLane; W W Winder; J O Holloszy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  238     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R328-32     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose
Dietary Carbohydrates / pharmacology
Fatty Acids, Nonesterified / blood
Glucagon / blood
Glycogen / biosynthesis*
Hydroxybutyrates / blood
Insulin / blood
Lactates / blood
Liver / metabolism
Liver Glycogen / biosynthesis*
Male
Muscles / metabolism*
Physical Exertion*
Rats
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Lactates; 0/Liver Glycogen; 11061-68-0/Insulin; 9005-79-2/Glycogen; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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