| Preferential oxygen supply to the brain and upper body in the fetal pig. | |
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MedLine Citation:
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PMID: 3364294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the fetal pig over 50% of the oxgenated umbilical venous blood bypasses the liver via vascular channels of over 100mu diameter which appear to act as a ductus venosus (DV). In the present experiments the oxygen levels (pO2, SO2 and O2 content) in the fetal carotid (CA) and femoral (FA) arteries were measured to determine whether preferential streaming of the oxygenated blood is maintained from the bypass to the foramen ovale and thence through the left heart to the upper body, as in other species. The results were obtained from 12 piglets catheterized and maintained in utero under sodium pentobarbitone anaesthesia. Significant CA-FA differences in pO2, SO2 and O2 content were observed in these fetuses during both normoxaemia and hypoxaemia showing that a higher level of oxygen can be maintained to the fetal head and brain over a wide range of oxygenation. These results confirm that the hepatic channels in the fetal piglet act as a fully functional DV. |
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Authors:
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M Silver; R J Barnes; A L Fowden; R S Comline |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 222 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-06-09 Completed Date: 1988-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 683-7 Citation Subset: IM |
Affiliation:
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Physiological Laboratory, Cambridge, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebrovascular Circulation* Female Fetal Blood / metabolism Fetus / physiology* Liver Circulation Oxygen / blood* Partial Pressure Pregnancy Regional Blood Flow* Swine Umbilical Veins / physiology |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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