| Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles. | |
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MedLine Citation:
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PMID: 18836572 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nanoparticles are increasingly being recognized for their potential utility in biological applications including nanomedicine. Here we examine the response of normal human cells to ZnO nanoparticles under different signaling environments and compare it to the response of cancerous cells. ZnO nanoparticles exhibit a strong preferential ability to kill cancerous T cells ( approximately 28-35x) compared to normal cells. Interestingly, the activation state of the cell contributes toward nanoparticle toxicity, as resting T cells display a relative resistance while cells stimulated through the T cell receptor and CD28 costimulatory pathway show greater toxicity in direct relation to the level of activation. Mechanisms of toxicity appear to involve the generation of reactive oxygen species, with cancerous T cells producing higher inducible levels than normal T cells. In addition, nanoparticles were found to induce apoptosis and the inhibition of reactive oxygen species was found to be protective against nanoparticle induced cell death. The novel findings of cell selective toxicity, towards potential disease causing cells, indicate a potential utility of ZnO nanoparticles in the treatment of cancer and/or autoimmunity. |
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Authors:
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Cory Hanley; Janet Layne; Alex Punnoose; K M Reddy; Isaac Coombs; Andrew Coombs; Kevin Feris; Denise Wingett |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nanotechnology Volume: 19 ISSN: 0957-4484 ISO Abbreviation: Nanotechnology Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2011-07-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
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Languages: eng Pagination: 295103 Citation Subset: - |
Affiliation:
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Department of Biological Sciences, Boise State University, Boise, ID 83725, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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