Document Detail

Preferential expression of L-type amino acid transporter 1 in ameloblasts during rat tooth development.
MedLine Citation:
PMID:  15027953     Owner:  NLM     Status:  MEDLINE    
Certain amino acid transport systems play an important role in supplying organic nutrients to each cell and for cell proliferation during tooth development. However, the mechanisms responsible for such actions are unclear. This study demonstrated for the first time that LAT1 and 4F2hc are expressed during tooth development in prenatal and postnatal rats, and that the transporters show cell-specific expression in ameloblasts, which are the epithelium-derived dental cells. LAT1 and 4F2hc expression was not observed in other dental cells of the developing teeth such as odontoblasts and cementoblasts. Overall, these results suggest that LAT1 and 4F2hc might play an important role in enamel formation.
J-C Park; Y B Kim; J H Yoon; H-J Kim; S M Kim; Y Kanai; H Endou; D K Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomia, histologia, embryologia     Volume:  33     ISSN:  0340-2096     ISO Abbreviation:  Anat Histol Embryol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-18     Completed Date:  2004-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704218     Medline TA:  Anat Histol Embryol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
Oral Biology Research Institute, College of Dentistry, Chosun University, 375 Seo-Suk Dong, Dong-ku, Gwang-ju, 501-759, Korea.
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MeSH Terms
Ameloblasts / metabolism*
Amino Acid Transport Systems / metabolism
Cell Division
Immunohistochemistry / veterinary
Large Neutral Amino Acid-Transporter 1 / metabolism*
Rats, Sprague-Dawley
Tooth / cytology,  growth & development*
Reg. No./Substance:
0/Amino Acid Transport Systems; 0/Large Neutral Amino Acid-Transporter 1

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