Document Detail


Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.
MedLine Citation:
PMID:  23149661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic inappropriate immune activation is the central defect-driving loss of CD4(+) T helper cells and progression to AIDS in persons with HIV-1 infection, but the mechanisms remain controversial. We examined key regulatory invariant receptor natural killer T (iNKT) cells in the gut, the largest reservoir of lymphocytes and a key arena of HIV-1 pathogenesis. In healthy control persons, the anti-inflammatory CD4(+) iNKT-cell subset predominated over the pro-inflammatory CD4(-) iNKT-cell subset in the gut, but not in the blood, compartment. HIV-1 infection resulted in a preferential loss of this anti-inflammatory CD4(+) iNKT-cell subset within the gut. The degree of loss of the CD4(+) iNKT-cell subset in the gut, but not in the blood, correlated to the systemic immune activation and exhaustion that have been linked to disease progression. These results suggest a potentially important contribution of gut iNKT-cell imbalance in determining the systemic immune activation that is the hallmark of HIV-1 pathogenesis.
Authors:
F J Ibarrondo; S B Wilson; L E Hultin; R Shih; M A Hausner; P M Hultin; P A Anton; B D Jamieson; O O Yang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-14
Journal Detail:
Title:  Mucosal immunology     Volume:  6     ISSN:  1935-3456     ISO Abbreviation:  Mucosal Immunol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-17     Completed Date:  2013-11-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101299742     Medline TA:  Mucosal Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  591-600     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD4 / metabolism
Cell Death
Disease Progression
HIV Infections / immunology*
HIV-1 / immunology*
Humans
Immunomodulation
Intestines / immunology*,  virology
Lymphocyte Count
Lymphocyte Depletion*
Male
Middle Aged
Natural Killer T-Cells / immunology*,  virology
Virus Activation / immunology
Young Adult
Grant Support
ID/Acronym/Agency:
AI028697/AI/NIAID NIH HHS; AI063974/AI/NIAID NIH HHS; P30 AI028697/AI/NIAID NIH HHS; R21 AI063974/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD4
Comments/Corrections

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