Document Detail


Preferential decarboxylation of L-threo-3,4-dihydroxyphenylserine in rat renal tissues.
MedLine Citation:
PMID:  8482506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Administration of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS; 3, 10 and 30 mg/kg, i.p.) produced a dose-dependent increase in the tissue levels of both noradrenaline and its deaminated metabolite 3,4-dihydroxyphenylglycol (DOPEG) in the rat jejunum, liver and renal cortex, but not in the left ventricle. 2. The accumulation of noradrenaline and DOPEG after the administration of L-threo-DOPS (30 mg/kg, i.p.) was also found to be a time-dependent effect, reaching its maximum 15 min after the injection and then declining progressively. 3. The accumulation of noradrenaline and DOPEG after L-threo-DOPS (30 mg/kg, i.p.) was found to be similar in control and 6-OHDA treated rats and completely prevented by previous treatment with benserazide. 4. Administration of L-threo-DOPS (30 mg/kg) produced an increase in plasma levels of noradrenaline and DOPEG; this effect was maximum, for both noradrenaline (6.2-fold increase) and DOPEG (3.4-fold increase), at 30 min after the injection of L-threo-DOPS. 5. The results presented here support the view that most L-threo-DOPS is decarboxylated into noradrenaline by non-neuronal AAAD, a reaction occurring predominantly in renal tissues.
Authors:
P Soares-da-Silva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General pharmacology     Volume:  24     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-05-28     Completed Date:  1993-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aromatic-L-Amino-Acid Decarboxylases / metabolism
Benserazide / pharmacology
Droxidopa / metabolism*
Heart Ventricles / enzymology,  metabolism
Jejunum / enzymology,  metabolism
Kidney / metabolism*
Kidney Cortex / enzymology,  metabolism
Liver / enzymology,  metabolism
Male
Methoxyhydroxyphenylglycol / analogs & derivatives,  blood,  metabolism
Norepinephrine / blood,  metabolism
Oxidopamine / pharmacology
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
1199-18-4/Oxidopamine; 23651-95-8/Droxidopa; 322-35-0/Benserazide; 3343-19-9/dihydroxyphenylethylene glycol; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; EC 4.1.1.28/Aromatic-L-Amino-Acid Decarboxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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