Document Detail


Preferential chromosome loss in human papilloma virus DNA-immortalized mammary epithelial cells.
MedLine Citation:
PMID:  1384674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human papilloma virus (HPV) DNA-immortalized human mammary epithelial cells may provide a model system for studying the molecular basis of immortalization and its role in breast neoplasia. Cytogenetic analyses were performed on clones derived from HPV 16- and HPV 18-immortalized human mammary epithelial cells. The majority of the clones contained near-diploid karyotypes. The single most frequent whole-chromosome loss was that of chromosome 19. Regions that showed preference for deletion and/or translocation included 2pter, 11qter, and 15pter. Evidence of chromosome 19 loss was confirmed by polymerase chain reaction (PCR)-generated, chromosome 19-specific, dinucleotide microsatellite repeat polymorphism analysis.
Authors:
K Swisshelm; M Leonard; R Sager
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  5     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-08     Completed Date:  1992-12-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Affiliation:
Division of Cancer Genetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Breast / microbiology,  ultrastructure*
Cell Line, Transformed
Cell Transformation, Viral / genetics*
Chromosome Aberrations*
Chromosome Deletion
Chromosomes, Human, Pair 19*
DNA, Viral / genetics
Female
Humans
Karyotyping
Papillomaviridae / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic / genetics
Repetitive Sequences, Nucleic Acid / genetics
Transfection
Grant Support
ID/Acronym/Agency:
CA39814/CA/NCI NIH HHS; T32 CA09361-12/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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