| Preferential adherence to immunosuppressive over nonimmunosuppressive medications in kidney transplant recipients. | |
| | |
MedLine Citation:
|
PMID: 21094819 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Successful kidney transplantation continues to be associated with an increased risk of death from cardiovascular disease. Treatment for hypertension, hyperlipidemia, and hyperglycemia adds to the pre-existing medication burden of immunosuppression. We postulated that patients are selectively adherent, preferentially taking some medications and choosing not to take others. To test this hypothesis, a random cross-sectional sample of outpatient kidney transplant recipients was interviewed by a person previously unknown to them using a structured closed-ended interview. Nonadherence was defined as missing any dose of medication over the preceding 1 month. By this criteria, 18.4% of patients were nonadherent to immunosuppressive medications, whereas 44.9% of patients were nonadherent to nonimmunosuppressive medication (antihypertensives, antidiabetic agents, and lipid-lowering agents). More patients were selectively nonadherent to their nonimmunosuppressive medications than to their immunosuppressive medications (P = .028). Patients who were nonadherent to nonimmunosuppressant medications were on a higher number of total medications and were more likely to be diabetic. We conclude that patients are more likely to miss or change doses of nonimmunosuppressive medications than immunosuppressive medications. The importance of nonimmunosuppressive medications must also be stressed at clinic visits to facilitate adherence to all classes of medication. Whether nonadherence to medications that treat cardiovascular risk factors contributes to the persistently high cardiovascular death rate in kidney transplant recipients remains to be determined. |
| | |
Authors:
|
S Terebelo; M Markell |
Related Documents
:
|
15957569 - Medication compliance during a smoking cessation clinical trial: a brief intervention u... 17101639 - Effect of a pharmacy care program on medication adherence and persistence, blood pressu... 12693439 - Predictors of risk of nonadherence in outpatients with schizophrenia and other psychoti... 2641329 - Attributions of responsibility in adolescent cancer patients and their parents. 20639269 - Improving self-report measures of medication non-adherence using a cheating detection e... 19109809 - Comparison of various measures for assessing medication refill adherence using prescrip... 1770499 - The carbon dioxide laser scalpel. 820549 - Epilepsy, a product of trauma in our time. 12364469 - Elevated regional lipolysis in hyperthyroidism. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
|
Languages: eng Pagination: 3578-85 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
SUNY Downstate Medical Center, Brooklyn, New York 11203, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantiferon-CMV test in prediction of cytomegalovirus infection after kidney transplantation.
Next Document: Anxiety, depression and emotional profile in renal transplant recipients and healthy subjects: a com...