Document Detail


Preexisting cognitive impairment in patients scheduled for elective coronary artery bypass graft surgery.
MedLine Citation:
PMID:  17456647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An accurate assessment of the prevalence of cognitive impairment in patients scheduled for coronary artery bypass graft (CABG) surgery is necessary if valid assumptions regarding cognitive change are to be made. Such an assessment requires the use of a healthy control group free of cardiovascular disease. METHODS: In a retrospective observational study, 349 patients scheduled for CABG surgery underwent neuropsychological testing. We compared the results with those from a group of 170 healthy controls without cardiovascular disease and containing more female patients who were matched for age and IQ score. Cognitive impairment was defined as test scores > or =2 sd less than the controls on two or more of the seven tests. RESULTS: The CABG surgery patients performed significantly worse than the control group on all tests except the Grooved Pegboard test (nondominant). When analyzed by group, performance on the verbal learning test was the most impaired. Cognitive impairment was present in 122 (35%) of CABG surgery patients before their procedure. Prior myocardial infarction, age, and IQ were independent predictors of cognitive impairment. CONCLUSIONS: Cognitive impairment is prevalent in patients presenting for CABG surgery. Impaired cognition before surgery must be considered when assessing the effects of CABG surgery on cognitive performance.
Authors:
Brendan S Silbert; David A Scott; Lisbeth A Evered; Matthew S Lewis; Paul T Maruff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  104     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-25     Completed Date:  2007-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1023-8, tables of contents     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesia, Centre for Anaesthesia and Cognitive Function, St. Vincent's Hospital, Melbourne, Australia. brendan.silbert@svhm.org.au
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MeSH Terms
Descriptor/Qualifier:
Aged
Cognition Disorders / diagnosis*,  psychology*
Coronary Artery Bypass* / psychology
Female
Humans
Male
Middle Aged
Neuropsychological Tests*
Preoperative Care / methods
Retrospective Studies
Surgical Procedures, Elective* / psychology
Comments/Corrections
Comment In:
Anesth Analg. 2007 May;104(5):1012-4   [PMID:  17456645 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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