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Preexercise Aminoacidemia and Muscle Protein Synthesis after Resistance Exercise.
MedLine Citation:
PMID:  22617396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: We have previously shown that the aminoacidemia caused by the consumption of a rapidly digested protein after resistance exercise enhances muscle protein synthesis (MPS) more than the amino acid (AA) profile associated with a slowly digested protein. Here, we investigated whether differential feeding patterns of a whey protein mixture commencing prior to exercise affect post-exercise intracellular signaling and muscle protein synthesis (MPS). METHODS: Twelve resistance-trained males performed leg resistance exercise 45 min after commencing each of three volume-matched nutrition protocols: placebo (PLAC; artificially sweetened water); BOLUS (25 g whey protein + 5 g leucine dissolved in artificially sweetened water; 1 × 500 mL); or PULSE (15 × 33 mL aliquots of BOLUS drink every 15 min). RESULTS: The pre-exercise rise in plasma AA concentration with PULSE was attenuated compared with BOLUS (P<0.05); this effect was reversed following exercise, with two-fold greater leucine concentrations in PULSE compared to BOLUS (P<0.05). One-hour post-exercise, phosphorylation of p70 S6K and rpS6 was increased above baseline with BOLUS and PULSE, but not PLAC (P<0.05); furthermore, PULSE > BOLUS (P<0.05). MPS throughout 5 h of recovery was higher with protein ingestion compared with PLAC (0.037 ±0.007) with no differences between BOLUS or PULSE (0.085 ±0.013 vs 0.095 ±0.010 %·h respectively, P = 0.56). CONCLUSIONS: Manipulation of aminoacidemia prior to resistance exercise via different patterns of intake of protein, altered plasma AA profiles and post-exercise intracellular signaling. However, there was no difference in the enhancement of the muscle protein synthetic response after exercise. Protein sources producing a slow AA release, when consumed before resistance exercise in sufficient amounts, are as effective as rapidly digested proteins in promoting post-exercise muscle protein synthesis.
Authors:
Louise M Burke; John A Hawley; Megan L Ross; Daniel R Moore; Stuart M Phillips; Gary R Slater; Trent Stellingwerff; Kevin D Tipton; Andrew P Garnham; Vernon G Coffey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-21
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Sports Nutrition, Australian Institute of Sport, Canberra, ACT, Australia 2Health Innovations Research Institute, School of Medical Sciences, RMIT University, Victoria, Australia 3Nestlé Research Center, Nestec Ltd., Lausanne, Switzerland 4Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. 5School of Sport, University of Stirling, Stirling, Scotland 6School of Health Sciences, Deakin University, Burwood, Victoria, Australia.
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