Document Detail

Preeclampsia, trisomy 13, and the placental bed.
MedLine Citation:
PMID:  1870809     Owner:  NLM     Status:  MEDLINE    
Genetic predisposition and abnormal trophoblastic function are thought to contribute to the development of preeclampsia. A multipara developed severe preeclampsia and subsequently delivered a live growth-retarded infant with trisomy 13. Biopsy of the placental bed taken immediately after delivery demonstrated inadequate trophoblastic remodeling of the maternal uterine vasculature, with an absence of normal physiologic changes in the spiral arteries. This case suggests that fetal trisomy 13 can be associated with preeclampsia in multiparous women and that abnormal trophoblastic invasion may contribute to the pathophysiology.
R F Feinberg; H J Kliman; A W Cohen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  78     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-16     Completed Date:  1991-09-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia.
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MeSH Terms
Chromosomes, Human, Pair 13*
Fetal Diseases / genetics*
Fetal Growth Retardation / etiology
Placenta Diseases / pathology
Pre-Eclampsia / genetics*

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