Document Detail

Preeclampsia and the systemic inflammatory response.
MedLine Citation:
PMID:  15529291     Owner:  NLM     Status:  MEDLINE    
Normal pregnancy is associated with a systemic inflammatory response. The response is exacerbated in preeclampsia and can account for its clinical features. Many of the physiologic changes of normal pregnancy are part of an acute-phase reaction, which is generated by an inflammatory response. The placenta is the proximal cause of these problems. There are several possible placental factors that may evoke the inflammatory responses that currently are being investigated. The special susceptibility of obese women, or those with diabetes or chronic hypertension, to preeclampsia is explained by the chronic systemic inflammatory responses that these women have. The clinical implications of these concepts are discussed.
Christopher W G Redman; Ian L Sargent
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  24     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-05     Completed Date:  2005-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  565-70     Citation Subset:  IM    
Department of Obstetric Medicine, University of Oxford, Oxford, UK.
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MeSH Terms
Inflammation / immunology
Placenta / immunology
Pre-Eclampsia / immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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