| Preeclampsia and the risk of end-stage renal disease. | |
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MedLine Citation:
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PMID: 18716297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is unknown whether preeclampsia is a risk marker for subsequent end-stage renal disease (ESRD). METHODS: We linked data from the Medical Birth Registry of Norway, which contains data on all births in Norway since 1967, with data from the Norwegian Renal Registry, which contains data on all patients receiving a diagnosis of end-stage renal disease (ESRD) since 1980, to assess the association between preeclampsia in one or more pregnancies and the subsequent development of ESRD. The study population consisted of women who had had a first singleton birth between 1967 and 1991; we included data from up to three pregnancies. RESULTS: ESRD developed in 477 of 570,433 women a mean (+/-SD) of 17+/-9 years after the first pregnancy (overall rate, 3.7 per 100,000 women per year). Among women who had been pregnant one or more times, preeclampsia during the first pregnancy was associated with a relative risk of ESRD of 4.7 (95% confidence interval [CI], 3.6 to 6.1). Among women who had been pregnant two or more times, preeclampsia during the first pregnancy was associated with a relative risk of ESRD of 3.2 (95% CI, 2.2 to 4.9), preeclampsia during the second pregnancy with a relative risk of 6.7 (95% CI, 4.3 to 10.6), and preeclampsia during both pregnancies with a relative risk of 6.4 (95% CI, 3.0 to 13.5). Among women who had been pregnant three or more times, preeclampsia during one pregnancy was associated with a relative risk of ESRD of 6.3 (95% CI, 4.1 to 9.9), and preeclampsia during two or three pregnancies was associated with a relative risk of 15.5 (95% CI, 7.8 to 30.8). Having a low-birth-weight or preterm infant increased the relative risk of ESRD. The results were similar after adjustment for possible confounders and after exclusion of women who had kidney disease, rheumatic disease, essential hypertension, or diabetes mellitus before pregnancy. CONCLUSIONS: Although the absolute risk of ESRD in women who have had preeclampsia is low, preeclampsia is a marker for an increased risk of subsequent ESRD. |
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Authors:
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Bjørn Egil Vikse; Lorentz M Irgens; Torbjørn Leivestad; Rolv Skjaerven; Bjarne M Iversen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The New England journal of medicine Volume: 359 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-08-28 Revised Date: 2009-04-06 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 800-9 Citation Subset: AIM; IM |
Copyright Information:
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2008 Massachusetts Medical Society |
Affiliation:
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Renal Research Group, Institute of Medicine, Haukeland University Hospital, Bergen 5021, Norway. bjorn.vikse@med.uib.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Follow-Up Studies Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Kidney Failure, Chronic / epidemiology, etiology* Norway / epidemiology Parity Pre-Eclampsia* Pregnancy Registries Risk Factors |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 2008 Aug 21;359(8):858-60
[PMID:
18716304
]
Nat Clin Pract Nephrol. 2009 Jan;5(1):8-9 [PMID: 19002136 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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