Document Detail

Preeclampsia: current understanding of the molecular basis of vascular dysfunction.
MedLine Citation:
PMID:  16438753     Owner:  NLM     Status:  MEDLINE    
Preeclampsia is a pregnancy-specific disorder characterised by hypertension and proteinuria occurring after the 20th week of gestation. Delivery of the placenta results in resolution of the condition, implicating the placenta as a central culprit in the pathogenesis of preeclampsia. In preeclampsia, an inadequate placental trophoblast invasion of the maternal uterine spiral arteries results in poor placental perfusion, leading to placental ischaemia. This could result in release of factors into the maternal circulation that cause widespread activation or dysfunction of the maternal endothelium. Factors in the maternal circulation might induce oxidative stress and/or elicit an inflammatory response in the maternal endothelium, resulting in the altered expression of several genes involved in the regulation of vascular tone. This review addresses the potential circulating factors and the molecular mechanisms involved in the alteration of vascular function that occurs in preeclampsia.
Sowndramalingam Sankaralingam; Ivan A Arenas; Manoj M Lalu; Sandra T Davidge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-01-26
Journal Detail:
Title:  Expert reviews in molecular medicine     Volume:  8     ISSN:  1462-3994     ISO Abbreviation:  Expert Rev Mol Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-27     Completed Date:  2007-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939725     Medline TA:  Expert Rev Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-20     Citation Subset:  IM    
Department of Physiology, Perinatal Research Centre, 232 HMRC, University of Alberta, Edmonton, AB, T6G 2S2, Canada.
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MeSH Terms
Blood Vessels / physiopathology
Endothelium, Vascular / physiopathology*
Oxidative Stress
Placenta / blood supply*,  physiopathology*
Pre-Eclampsia / etiology*
Proteins / metabolism
Reg. No./Substance:

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