| Preeclampsia is associated with increased cytotoxic T-cell capacity to paternal antigens. | |
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MedLine Citation:
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PMID: 20723874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: During an uncomplicated pregnancy the conceptus is a semiallogeneic entity in which rejection is prevented by suppression of the maternal immune system. We hypothesized that this suppression is disturbed in patients with preeclampsia and that a maternal immune response to fetal (foreign/paternal) antigens in the fetal-maternal interface may be responsible for local inflammation, with subsequent endothelial dysfunction and systemic disease. STUDY DESIGN: Blood samples were obtained from 14 women with preeclampsia (cases), 14 gestational-age and parity-matched women with uncomplicated pregnancies (controls), and their partners. We determined the partner-specific cytotoxic T-lymphocyte precursor frequency (CTLpf) and the CTLpf directed to unrelated partners with uncomplicated pregnancies. We measured the CTLpf in peripheral blood mononuclear cells (PBMCs) from cases and controls using limited-dilution assays. In addition, proliferation was tested in a mixed-lymphocyte culture (MLR). RESULTS: The partner-specific CTLpf was significantly higher in cases compared with controls (median, 183 [15-338] vs 67 [9-232] per million PBMCs, P = .02). In contrast, in women with uncomplicated pregnancies, the partner-specific CTLpf was down-regulated compared with the CTLpf directed to an unrelated partner who fathered uncomplicated pregnancies (P = .02). No difference was found in partner-specific MLR response between cases and controls. CONCLUSION: These results suggest that women with preeclampsia have a higher cytotoxic T-cell response to paternal antigens compared with pregnant controls. This insufficiently suppressed immune response may eventually lead to the development of preeclampsia. |
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Authors:
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Christianne J M de Groot; Barbara J van der Mast; Willy Visser; Petronella De Kuiper; Willem Weimar; Nicole M Van Besouw |
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Publication Detail:
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Type: Journal Article Date: 2010-08-17 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 496.e1-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands. cdegroot@me.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens / immunology* Cells, Cultured Female Humans Lymphocyte Culture Test, Mixed Male Pre-Eclampsia / immunology* Pregnancy Statistics, Nonparametric T-Lymphocytes, Cytotoxic / cytology, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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