Document Detail

Preeclampsia is associated with global cerebral hemodynamic changes.
MedLine Citation:
PMID:  15866116     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare blood flow-velocity parameters in the anterior and posterior cerebral arteries between normotensive and preeclamptic pregnant women. METHODS: Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in the anterior cerebral artery (ACA) and posterior cerebral artery (PCA) of 22 normotensive and 12 preeclamptic women in the third trimester. All measurements were performed with the subject in the left lateral position. Blood pressure and heart rate were recorded with each Doppler measurement. The mean pulsatility index (PI), resistance index (RI), and cerebral perfusion pressure for each artery was averaged and compared. Statistical significance was set at P <.05. RESULTS: Preeclamptic women had higher cerebral perfusion pressure in both ACA and PCA (64.7 +/- 5.9 and 78.1 +/- 7.6 compared with 42.4 +/- 2.6 and 54.1 +/- 4.1 mmHg, P <.05), lower PI (0.83 +/- 0.05 and 0.71 +/- 0.04 compared with 0.96 +/- 0.04 and 0.84 +/- 0.02, P <.05), and lower RI (0.55 +/- 0.02 and 0.49 +/- 0.02 compared with 0.60 +/- 0.02 and 0.55 +/- 0.01, P <.05) than normotensive pregnant women. CONCLUSION: Preeclamptic patients have globally elevated cerebral perfusion pressure and lower resistance in the cerebral circulation than normotensive pregnant women.
Shlomit Riskin-Mashiah; Michael A Belfort
Related Documents :
20857796 - Safety, efficacy and acceptability of implanon a single rod implantable contraceptive (...
20176996 - Blood pressure and vascular calcification.
16278616 - Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensiv...
9794736 - Correlates of cognitive status of old patients with isolated systolic hypertension: the...
8542116 - Vascular injury in isolated sheep lungs. role of ischemia, extracorporeal perfusion, an...
2745286 - Effect on breathing of abruptly loading and unloading the canine left heart.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  12     ISSN:  1556-7117     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-03     Completed Date:  2006-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anterior Cerebral Artery / ultrasonography*
Blood Pressure
Brain / blood supply*
Case-Control Studies
Heart Rate
Pre-Eclampsia / physiopathology*
Pregnancy Trimester, Third
Regional Blood Flow
Ultrasonography, Doppler, Transcranial
Grant Support
M01-00188//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The measurement of dendritic cells in umbilical cord blood: a novel technique using small volumes of...
Next Document:  Differentiation of mouse embryonic stem cells into gonadotrope-like cells in vitro.