Document Detail


Preeclampsia is associated with global cerebral hemodynamic changes.
MedLine Citation:
PMID:  15866116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare blood flow-velocity parameters in the anterior and posterior cerebral arteries between normotensive and preeclamptic pregnant women. METHODS: Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in the anterior cerebral artery (ACA) and posterior cerebral artery (PCA) of 22 normotensive and 12 preeclamptic women in the third trimester. All measurements were performed with the subject in the left lateral position. Blood pressure and heart rate were recorded with each Doppler measurement. The mean pulsatility index (PI), resistance index (RI), and cerebral perfusion pressure for each artery was averaged and compared. Statistical significance was set at P <.05. RESULTS: Preeclamptic women had higher cerebral perfusion pressure in both ACA and PCA (64.7 +/- 5.9 and 78.1 +/- 7.6 compared with 42.4 +/- 2.6 and 54.1 +/- 4.1 mmHg, P <.05), lower PI (0.83 +/- 0.05 and 0.71 +/- 0.04 compared with 0.96 +/- 0.04 and 0.84 +/- 0.02, P <.05), and lower RI (0.55 +/- 0.02 and 0.49 +/- 0.02 compared with 0.60 +/- 0.02 and 0.55 +/- 0.01, P <.05) than normotensive pregnant women. CONCLUSION: Preeclamptic patients have globally elevated cerebral perfusion pressure and lower resistance in the cerebral circulation than normotensive pregnant women.
Authors:
Shlomit Riskin-Mashiah; Michael A Belfort
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  12     ISSN:  1556-7117     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-03     Completed Date:  2006-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA. shlomitriskin@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anterior Cerebral Artery / ultrasonography*
Blood Pressure
Brain / blood supply*
Case-Control Studies
Female
Heart Rate
Humans
Pre-Eclampsia / physiopathology*
Pregnancy
Pregnancy Trimester, Third
Regional Blood Flow
Ultrasonography, Doppler, Transcranial
Grant Support
ID/Acronym/Agency:
M01-00188//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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