Document Detail


Preeclampsia. Part 1: clinical and pathophysiologic considerations.
MedLine Citation:
PMID:  12218668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia-eclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. Despite active research for many years, the etiology of this disorder exclusive to human pregnancy is an enigma. Recent evidence suggests there may be several underlying causes or predispositions leading to the signs of hypertension, proteinuria, and edema, findings that allow us to make the diagnosis of the "syndrome" of preeclampsia. Despite improved prenatal care, severe preeclampsia and eclampsia still occur. Although understanding of the pathophysiology of these disorders has improved, treatment has not changed significantly in over 50 years. Although postponement of delivery in selected women with severe preeclampsia improves fetal outcome to a degree, this is not done without risk to the mother. In the United States, magnesium sulfate and hydralazine are the most commonly used medications for seizure prophylaxis and hypertension in the intrapartum period. The search for the underlying cause of this disorder and for a clinical marker to predict those women who will develop preeclampsia-eclampsia is ongoing, with its prevention the ultimate goal. This review begins with the clinical and pathophysiologic aspects of preeclampsia-eclampsia (Part 1). In Part 2, the experimental observations, the search for predictive factors, and the genetics of this disorder will be reviewed.
Authors:
Gabriella Pridjian; Jules B Puschett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Obstetrical & gynecological survey     Volume:  57     ISSN:  0029-7828     ISO Abbreviation:  Obstet Gynecol Surv     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-09     Completed Date:  2002-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401007     Medline TA:  Obstet Gynecol Surv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  598-618     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynecology, Tulane University Medical School, New Orleans, Louisiana 70112, USA. Gabriella.Pridjian@tulane.edu
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Female
Fetal Death
HELLP Syndrome / diagnosis
Humans
Hypertension / diagnosis,  etiology
Maternal Mortality
Pre-Eclampsia / diagnosis*,  etiology,  physiopathology*,  therapy
Pregnancy
Pregnancy Complications, Cardiovascular / diagnosis
Prognosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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