Document Detail


Preeclampsia and HELLP syndrome: impaired mitochondrial function in umbilical endothelial cells.
MedLine Citation:
PMID:  20065299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia (PE) and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome have been linked to congenital fetal disorders of mitochondrial fatty acid oxidation (FAO). Different incidences may argue for the association of noncongenital alterations of mitochondrial energy metabolism with PE/HELLP syndrome. We studied human umbilical vein endothelial cells [HUVEC] as selected part of the feto-placental unit from uncomplicated (n = 46) and diseased (n = 27; 17 PE and 10 HELLP) pregnancies by measuring the overall FAO, carnitine palmitoyltransferase 2 (CPT2), respiratory chain (RC) complexes I-V, citratesynthase (CS), lactatedehydrogenase (LDH), hexokinase (HK), phosphofructokinase (PFK), and energy rich phosphates. Maternal and infantile acylcarnitines in blood were investigated post partum. Overall FAO, RC complexes II-V, and CS were significantly compromised in HUVEC from complicated pregnancies; impairment of complexes I + III was not significant. CPT2 and energy charges were unaffected. Lactatedehydrogenase and PFK from complicated pregnancies were upregulated, and HK remained constant. In blood, carnitine was elevated in diseased women and their children, acylcarnitines were higher in affected infants. Impaired mitochondrial function in HUVEC is associated with PE/HELLP syndrome and may be involved in the pathophysiology of these diseases.
Authors:
Sabine Illsinger; Nils Janzen; Stefanie Sander; Karl-Heinz Schmidt; Jolanthe Bednarczyk; Lisa Mallunat; Julia Bode; Friederike Hageb?lling; Ludwig Hoy; Thomas L?cke; Ralf Hass; Anibh M Das
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Publication Detail:
Type:  Journal Article     Date:  2010-01-11
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  17     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-12     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Affiliation:
Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany. illsinger.sabine@mh-hannover.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Carnitine / analogs & derivatives,  blood
Carnitine O-Palmitoyltransferase / metabolism
Citrate (si)-Synthase / metabolism
Electron Transport
Endothelial Cells / enzymology,  metabolism*,  ultrastructure
Energy Metabolism
Fatty Acids / metabolism
Female
Glycolysis
HELLP Syndrome / etiology,  metabolism*
Humans
Infant, Newborn
L-Lactate Dehydrogenase / metabolism
Mitochondria / enzymology,  metabolism*
Mitochondrial Diseases / complications,  enzymology,  metabolism*
Multienzyme Complexes / metabolism
Oxidation-Reduction
Phosphofructokinases / metabolism
Pre-Eclampsia / etiology,  metabolism*
Pregnancy
Umbilical Veins*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Multienzyme Complexes; 0/acylcarnitine; 541-15-1/Carnitine; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.3.1.21/Carnitine O-Palmitoyltransferase; EC 2.3.3.1/Citrate (si)-Synthase; EC 2.7.1 -/Phosphofructokinases

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