Document Detail


Preeclampsia and the Anti-Angiogenic State.
MedLine Citation:
PMID:  21709826     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide, however, its etiology remains unclear. Abnormal placental angiogenesis during pregnancy resulting from high levels of anti-angiogenic factors, soluble Flt1 (sFlt1) and soluble endoglin (sEng), has been implicated in preeclampsia pathogenesis. Accumulating evidence also points to a role for these anti-angiogenic proteins as serum biomarkers for the clinical diagnosis and prediction of preeclampsia. Uncovering the mechanisms of altered angiogenic factors in preeclampsia may also provide insights into novel preventive and therapeutic options.
Authors:
Isha Agarwal; S Ananth Karumanchi
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Pregnancy hypertension     Volume:  1     ISSN:  2210-7789     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101552483     Medline TA:  Pregnancy Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  17-21     Citation Subset:  -    
Affiliation:
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
//Howard Hughes Medical Institute

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