| Preeclampsia and the Anti-Angiogenic State. | |
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MedLine Citation:
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PMID: 21709826 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide, however, its etiology remains unclear. Abnormal placental angiogenesis during pregnancy resulting from high levels of anti-angiogenic factors, soluble Flt1 (sFlt1) and soluble endoglin (sEng), has been implicated in preeclampsia pathogenesis. Accumulating evidence also points to a role for these anti-angiogenic proteins as serum biomarkers for the clinical diagnosis and prediction of preeclampsia. Uncovering the mechanisms of altered angiogenic factors in preeclampsia may also provide insights into novel preventive and therapeutic options. |
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Authors:
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Isha Agarwal; S Ananth Karumanchi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Pregnancy hypertension Volume: 1 ISSN: 2210-7789 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101552483 Medline TA: Pregnancy Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: 17-21 Citation Subset: - |
Affiliation:
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Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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